A TRIM21-based bioPROTAC highlights the therapeutic benefit of HuR degradation

Human antigen R (HuR) is a ubiquitously expressed RNA-binding protein, which functions as an RNA regulator. Overexpression of HuR correlates with high grade tumours and poor patient prognosis, implicating it as an attractive therapeutic target. However, an effective small molecule antagonist to HuR...

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Detalles Bibliográficos
Autores principales: Fletcher, Alice, Clift, Dean, de Vries, Emma, Martinez Cuesta, Sergio, Malcolm, Timothy, Meghini, Francesco, Chaerkady, Raghothama, Wang, Junmin, Chiang, Abby, Weng, Shao Huan Samuel, Tart, Jonathan, Wong, Edmond, Donohoe, Gerard, Rawlins, Philip, Gordon, Euan, Taylor, Jonathan D., James, Leo, Hunt, James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10625600/
https://www.ncbi.nlm.nih.gov/pubmed/37925433
http://dx.doi.org/10.1038/s41467-023-42546-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10625600/
https://www.ncbi.nlm.nih.gov/pubmed/37925433
http://dx.doi.org/10.1038/s41467-023-42546-2

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