Cargando…

IL-21R-STAT3 signalling initiates a differentiation program in uterine tissue-resident NK cells to support pregnancy

Tissue-resident Natural Killer (trNK) cells are crucial components of local immunity that activate rapidly upon infection. However, under steady state conditions, their responses are tightly controlled to prevent unwanted tissue damage. The mechanisms governing their differentiation and activation a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Han, Mengwei, Hu, Luni, Wu, Di, Zhang, Yime, Li, Peng, Zhao, Xingyu, Zeng, Yanyu, Ren, Guanqun, Hou, Zhiyuan, Pang, Yanli, Zhao, Tongbiao, Zhong, Chao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10625623/ https://www.ncbi.nlm.nih.gov/pubmed/37925507 http://dx.doi.org/10.1038/s41467-023-42990-0

Ejemplares similares

Genetic distinction between functional tissue-resident and conventional natural killer cells
por: Hu, Luni, et al.
Publicado: (2023)

Proximal and Distal Regions of Pathogenic Th17 Related Chromatin Loci Are Sequentially Accessible During Pathogenicity of Th17
por: Hu, Luni, et al.
Publicado: (2022)

NK Cell IL-10 Production Requires IL-15 and IL-10 Driven STAT3 Activation
por: Clark, Sarah E., et al.
Publicado: (2019)

Abnormal Epigenetic Regulations in the Immunocytes of Sjögren’s Syndrome Patients and Therapeutic Potentials
por: Li, Peng, et al.
Publicado: (2022)

Membrane bound IL-21 based NK cell feeder cells drive robust expansion and metabolic activation of NK cells
por: Ojo, Evelyn O., et al.
Publicado: (2019)

STAT3 governs the HIF-1α response in IL-15 primed human NK cells
por: Coulibaly, Anna, et al.
Publicado: (2021)

Overexpression of microRNA-155 increases IL-21 mediated STAT3 signaling and IL-21 production in systemic lupus erythematosus
por: Rasmussen, Tue Kruse, et al.
Publicado: (2015)

Chimeric antigen receptor T (CAR-T) cells expanded with IL-7/IL-15 mediate superior antitumor effects
por: Zhou, Jianxia, et al.
Publicado: (2019)

STATs in NK-Cells: The Good, the Bad, and the Ugly
por: Gotthardt, Dagmar, et al.
Publicado: (2017)

The effect of pregnancy on the uterine NK cell KIR repertoire
por: Male, Victoria, et al.
Publicado: (2011)

FGF21 Depletion Attenuates Colitis through Intestinal Epithelial IL-22-STAT3 Activation in Mice
por: Liu, Liming, et al.
Publicado: (2023)

IL-6 and IL-8 secreted by tumour cells impair the function of NK cells via the STAT3 pathway in oesophageal squamous cell carcinoma
por: Wu, Jian, et al.
Publicado: (2019)

STAT3 Dysregulation in Mature T and NK Cell Lymphomas
por: Seffens, Angelina, et al.
Publicado: (2019)

Evaluation of allogeneic and autologous membrane-bound IL-21–expanded NK cells for chronic lymphocytic leukemia therapy
por: Yano, Max, et al.
Publicado: (2022)

IL-21-dependent expansion of memory-like NK cells enhances protective immune responses against Mycobacterium tuberculosis
por: Venkatasubramanian, Sambasivan, et al.
Publicado: (2016)

The Multifaceted Role of STAT3 in NK-Cell Tumor Surveillance
por: Witalisz-Siepracka, Agnieszka, et al.
Publicado: (2022)

Functional enhancement of exosomes derived from NK cells by IL-15 and IL-21 synergy against hepatocellular carcinoma cells: The cytotoxicity and apoptosis in vitro study
por: Kim, In-Young, et al.
Publicado: (2023)

Uterine Microbiota: Residents, Tourists, or Invaders?
por: Baker, James M., et al.
Publicado: (2018)

Porphyromonas gingivalis-mediated disruption in spiral artery remodeling is associated with altered uterine NK cell populations and dysregulated IL-18 and Htra1
por: Tavarna, Tanvi, et al.
Publicado: (2022)

Clinical application and prospect of immune checkpoint inhibitors for CAR-NK cell in tumor immunotherapy
por: Yang, Kangdi, et al.
Publicado: (2023)

IL-21-mediated reversal of NK cell exhaustion facilitates anti-tumour immunity in MHC class I-deficient tumours
por: Seo, Hyungseok, et al.
Publicado: (2017)

Expansion of Human NK Cells Using K562 Cells Expressing OX40 Ligand and Short Exposure to IL-21
por: Kweon, SoonHo, et al.
Publicado: (2019)

IL-21 and IFNα therapy rescues terminally differentiated NK cells and limits SIV reservoir in ART-treated macaques
por: Harper, Justin, et al.
Publicado: (2021)

Transcription Factors Associated With IL-15 Cytokine Signaling During NK Cell Development
por: Wang, Xiang, et al.
Publicado: (2021)

IL-21 in Homeostasis of Resident Memory and Exhausted CD8 T Cells during Persistent Infection
por: Ren, Heather M., et al.
Publicado: (2020)

Endometrial Tumor Microenvironment Alters Human NK Cell Recruitment, and Resident NK Cell Phenotype and Function
por: Degos, Clara, et al.
Publicado: (2019)

Unexpected role of STAT1 serine727 for NK cell function
por: Putz, Eva M, et al.
Publicado: (2009)

Emergence of a STAT3 mutated NK clone in LGL leukemia
por: Yan, Yiyi, et al.
Publicado: (2014)

JAK/STAT Cytokine Signaling at the Crossroad of NK Cell Development and Maturation
por: Gotthardt, Dagmar, et al.
Publicado: (2019)

Transcriptional, Epigenetic and Pharmacological Control of JAK/STAT Pathway in NK Cells
por: Scarno, Gianluca, et al.
Publicado: (2019)

Defective STAT1 activation associated with impaired IFN-γ production in NK and T lymphocytes from metastatic melanoma patients treated with IL-2
por: Sim, Geok Choo, et al.
Publicado: (2016)

IL-21/IL-21R Regulates the Neutrophil-Mediated Pathologic Immune Response during Chlamydial Respiratory Infection
por: Zeng, Jiajia, et al.
Publicado: (2022)

Ovarian Stimulation Affects the Population of Mouse Uterine NK Cells at Early Pregnancy
por: Dorfeshan, Parvin, et al.
Publicado: (2013)

First do no harm: uterine natural killer (NK) cells in assisted reproduction
por: Moffett, Ashley, et al.
Publicado: (2015)

The role of extravillous trophoblasts and uterine NK cells in vascular remodeling during pregnancy
por: Wei, Xiao-Wei, et al.
Publicado: (2022)

IL-21 induces in vivo immune activation of NK cells and CD8(+) T cells in patients with metastatic melanoma and renal cell carcinoma
por: Frederiksen, Klaus Stensgaard, et al.
Publicado: (2008)

Differential roles of uterine epithelial and stromal STAT3 coordinate uterine receptivity and embryo attachment
por: Hiraoka, Takehiro, et al.
Publicado: (2020)

TL1A Selectively Enhances IL-12/IL-18-Induced NK Cell Cytotoxicity against NK-Resistant Tumor Targets
por: Heidemann, Stephanie C., et al.
Publicado: (2010)

Hepatic irradiation persistently eliminates liver resident NK cells
por: Nakano, Ryosuke, et al.
Publicado: (2018)

Tissue-Resident NK Cells: Development, Maturation, and Clinical Relevance
por: Hashemi, Elaheh, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_a0qtpm05h34eoah81nfre06nli