c-Myc uses Cul4b to preserve genome integrity and promote antiviral CD8(+) T cell immunity

During infection, virus-specific CD8(+) T cells undergo rapid bursts of proliferation and differentiate into effector cells that kill virus-infected cells and reduce viral load. This rapid clonal expansion can put T cells at significant risk for replication-induced DNA damage. Here, we find that c-M...

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Detalles Bibliográficos
Autores principales: Dar, Asif A., Kim, Dale D., Gordon, Scott M., Klinzing, Kathleen, Rosen, Siera, Guha, Ipsita, Porter, Nadia, Ortega, Yohaniz, Forsyth, Katherine S., Roof, Jennifer, Fazelinia, Hossein, Spruce, Lynn A., Eisenlohr, Laurence C., Behrens, Edward M., Oliver, Paula M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10625626/
https://www.ncbi.nlm.nih.gov/pubmed/37925424
http://dx.doi.org/10.1038/s41467-023-42765-7

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