Cargando…

High Expression of NRF2 and Low Expression of KEAP1 Predict Worse Survival in Patients With Operable Triple-Negative Breast Cancer

PURPOSE: Triple-negative breast cancer (TNBC) is an aggressive type of breast cancer. Currently, no effective treatment options for this condition exist. Nuclear factor erythroid 2-related factor 2 (NRF2), encoded by nuclear factor erythroid-derived 2-like 2 (NFE2L2) gene and its endogenous inhibito...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lee, Young Sub, Kang, Jun, Jung, Eun Sun, Lee, Ahwon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Korean Breast Cancer Society 2023
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10625868/ https://www.ncbi.nlm.nih.gov/pubmed/37926068 http://dx.doi.org/10.4048/jbc.2023.26.e42

Ejemplares similares

The Clinicopathological and Prognostic Significance of Nrf2 and Keap1 Expression in Hepatocellular Carcinoma
por: Lee, Kiryang, et al.
Publicado: (2020)

Adipogenesis in triple-negative breast cancer is associated with unfavorable tumor immune microenvironment and with worse survival
por: Oshi, Masanori, et al.
Publicado: (2021)

Clinical implication of Keap1 and phosphorylated Nrf2 expression in hepatocellular carcinoma
por: Chen, Jiang, et al.
Publicado: (2016)

High expression of miR-214 is associated with a worse disease-specific survival of the triple-negative breast cancer patients
por: Kalniete, Dagnija, et al.
Publicado: (2015)

Prognostic Role and Clinical Association of Tumor-Infiltrating Lymphocyte, Programmed Death Ligand-1 Expression with Neutrophil-Lymphocyte Ratio in Locally Advanced Triple-Negative Breast Cancer
por: Lee, Jieun, et al.
Publicado: (2019)

High expression of MORC2 predicts worse neoadjuvant chemotherapy efficacy in triple negative breast cancer
por: Liao, Xiaohong, et al.
Publicado: (2023)

The Role of NRF2/KEAP1 Signaling Pathway in Cancer Metabolism
por: Song, Moon-Young, et al.
Publicado: (2021)

Fascin expression is inversely correlated with breast cancer metastasis suppressor 1 and predicts a worse survival outcome in node-negative breast cancer patients
por: Lee, Hye Jin, et al.
Publicado: (2017)

The KEAP1–NRF2 System in Cancer
por: Taguchi, Keiko, et al.
Publicado: (2017)

Keap1/Nrf2 Signaling Pathway
por: Sykiotis, Gerasimos P.
Publicado: (2021)

Nuclear Expression of GS28 Protein: A Novel Biomarker that Predicts Worse Prognosis in Cervical Cancers
por: Cho, Uiju, et al.
Publicado: (2016)

Kahweol activates the Nrf2/HO-1 pathway by decreasing Keap1 expression independently of p62 and autophagy pathways
por: Seo, Hye-Young, et al.
Publicado: (2020)

Structural basis of Keap1 interactions with Nrf2
por: Canning, Peter, et al.
Publicado: (2015)

Epigenetic Regulation of NRF2/KEAP1 by Phytochemicals
por: Bhattacharjee, Shamee, et al.
Publicado: (2020)

The KEAP1/NRF2 Signaling Pathway in Keratinization
por: Ishitsuka, Yosuke, et al.
Publicado: (2020)

The KEAP1-NRF2 System and Esophageal Cancer
por: Hirose, Wataru, et al.
Publicado: (2022)

Modulation of NRF2/KEAP1 Signaling in Preeclampsia
por: Tossetta, Giovanni, et al.
Publicado: (2023)

Expression of Keap1 and Nrf2 in diffuse large B-cell lymphoma and its clinical significance
por: Yi, Xuemei, et al.
Publicado: (2018)

Evaluation of Nrf2, Keap1 and Apoptotic Pathway Genes Expression in Acute Myeloid Leukemia Patients
por: Jalali, Amir, et al.
Publicado: (2021)

A Naturally-Occurring Dominant-Negative Inhibitor of Keap1 Competitively against Its Negative Regulation of Nrf2
por: Qiu, Lu, et al.
Publicado: (2018)

Fatty acid synthetase expression in triple-negative breast cancer
por: Park, Jin Hee, et al.
Publicado: (2022)

IRF4 expression is low in Philadelphia negative myeloproliferative neoplasms and is associated with a worse prognosis
por: Cumbo, Cosimo, et al.
Publicado: (2021)

KEAP1 and done? Targeting the NRF2 pathway with sulforaphane
por: Dinkova-Kostova, Albena T., et al.
Publicado: (2017)

WDR23 regulates NRF2 independently of KEAP1
por: Lo, Jacqueline Y., et al.
Publicado: (2017)

Coumarins as Modulators of the Keap1/Nrf2/ARE Signaling Pathway
por: Hassanein, Emad H. M., et al.
Publicado: (2020)

Nrf2/Keap1/ARE signaling: Towards specific regulation
por: Ulasov, Alexey V., et al.
Publicado: (2022)

The KEAP1-NRF2 System in Healthy Aging and Longevity
por: Matsumaru, Daisuke, et al.
Publicado: (2021)

Molecular Basis of the KEAP1-NRF2 Signaling Pathway
por: Suzuki, Takafumi, et al.
Publicado: (2023)

Insights into the Regulation of GFR by the Keap1-Nrf2 Pathway
por: Kidokoro, Kengo, et al.
Publicado: (2023)

Role of Oxidative Stress and Nrf2/KEAP1 Signaling in Colorectal Cancer: Mechanisms and Therapeutic Perspectives with Phytochemicals
por: Lee, Da-Young, et al.
Publicado: (2021)

PRMT5 reduces immunotherapy efficacy in triple-negative breast cancer by methylating KEAP1 and inhibiting ferroptosis
por: Wang, Zhe, et al.
Publicado: (2023)

Negative Regulation of the Keap1-Nrf2 Pathway by a p62/Sqstm1 Splicing Variant
por: Kageyama, Shun, et al.
Publicado: (2018)

Physical and Functional Interaction of Sequestosome 1 with Keap1 Regulates the Keap1-Nrf2 Cell Defense Pathway
por: Copple, Ian M., et al.
Publicado: (2010)

Sonography with vertical orientation feature predicts worse disease outcome in triple negative breast cancer
por: Wang, Haoyu, et al.
Publicado: (2019)

Comparison of the expression levels of lysine-specific demethylase 1 and survival outcomes between triple-negative and non-triple-negative breast cancer
por: Zhao, Kangrong, et al.
Publicado: (2021)

Notch1 in Tumor Microvascular Endothelial Cells and Tumoral miR-34a as Prognostic Markers in Locally Advanced Triple-Negative Breast Cancer
por: Kim, Dongmin, et al.
Publicado: (2019)

Effects of Compound Centella on Oxidative Stress and Keap1-Nrf2-ARE Pathway Expression in Diabetic Kidney Disease Rats
por: Zhu, Qin, et al.
Publicado: (2020)

Low expression of NR1H3 correlates with macrophage infiltration and indicates worse survival in breast cancer
por: Zhang, Jing, et al.
Publicado: (2023)

Three-microRNA expression signature predicts survival in triple-negative breast cancer
por: Wu, Xinquan, et al.
Publicado: (2020)

Estrogen receptor beta expression in triple negative breast cancers is not associated with recurrence or survival
por: Takano, Elena A., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_n5h0k14l2j4h5ekltbvt49qmkb