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Identification of the methotrexate resistance-related diagnostic markers in osteosarcoma via adaptive total variation netNMF and multi-omics datasets

Osteosarcoma is one of the most common malignant bone tumors with high chemoresistance and poor prognosis, exhibiting abnormal gene regulation and epigenetic events. Methotrexate (MTX) is often used as a primary agent in neoadjuvant chemotherapy for osteosarcoma; However, the high dosage of methotre...

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Detalles Bibliográficos
Autores principales:	Jiang, Zhihan, Han, Kun, Min, Daliu, Kong, Wei, Wang, Shuaiqun, Gao, Min
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Genetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10625916/ https://www.ncbi.nlm.nih.gov/pubmed/37937197 http://dx.doi.org/10.3389/fgene.2023.1288073

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