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UPSIT subitems may predict motor progression in Parkinson’s disease
BACKGROUND: The relationship between hyposmia and motor progression is controversial in Parkinson’s disease (PD). The aim of this study was to investigate whether preserved identification of Chinese-validated University of Pennsylvania Smell Identification Test (UPSIT) odors could predict PD motor p...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10625917/ https://www.ncbi.nlm.nih.gov/pubmed/37936914 http://dx.doi.org/10.3389/fneur.2023.1265549 |
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author | Lin, Yu-Hsuan Fang, Ting-Chun Lei, Hsin-Bei Chiu, Shih-Chi Chang, Ming-Hong Guo, Yi-Jen |
author_facet | Lin, Yu-Hsuan Fang, Ting-Chun Lei, Hsin-Bei Chiu, Shih-Chi Chang, Ming-Hong Guo, Yi-Jen |
author_sort | Lin, Yu-Hsuan |
collection | PubMed |
description | BACKGROUND: The relationship between hyposmia and motor progression is controversial in Parkinson’s disease (PD). The aim of this study was to investigate whether preserved identification of Chinese-validated University of Pennsylvania Smell Identification Test (UPSIT) odors could predict PD motor progression. METHODS: PD patients with two consecutive clinical visits while taking medication were recruited. Based on mean changes in Movement Disorder Society Unified Parkinson’s Disease Rating Scale part 3 score and levodopa equivalent daily dosage, the participants were categorized into rapid progression, medium progression, and slow progression groups. Odors associated with the risk of PD motor progression were identified by calculating the odds ratios of UPSIT item identification between the rapid and slow progression groups. Receiver operating characteristic curve analysis of these odors was conducted to determine an optimal threshold for rapid motor progression. RESULTS: A total of 117 PD patients were screened for group classification. Preserved identification of neutral/pleasant odors including banana, peach, magnolia, and baby powder was significantly correlated with rapid motor progression. The risk of rapid progression increased with more detected risk odors. Detection of ≥1.5 risk odors could differentiate rapid progression from slow progression with a sensitivity of 85.7%, specificity of 45.8%, and area under the receiver operating characteristic curve of 0.687. CONCLUSION: Preserved identification of neutral/pleasant odors may help to predict PD motor progression, and detection of ≥1.5 UPSIT motor progression risk odors could improve the predictive power. In PD patients with a similar level of motor disability during initial screening, preserved pleasant/neutral odor identification may imply relatively better cortical odor discriminative function, which may suggest the body-first (caudo-rostral) subtype with faster disease progression. |
format | Online Article Text |
id | pubmed-10625917 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-106259172023-11-07 UPSIT subitems may predict motor progression in Parkinson’s disease Lin, Yu-Hsuan Fang, Ting-Chun Lei, Hsin-Bei Chiu, Shih-Chi Chang, Ming-Hong Guo, Yi-Jen Front Neurol Neurology BACKGROUND: The relationship between hyposmia and motor progression is controversial in Parkinson’s disease (PD). The aim of this study was to investigate whether preserved identification of Chinese-validated University of Pennsylvania Smell Identification Test (UPSIT) odors could predict PD motor progression. METHODS: PD patients with two consecutive clinical visits while taking medication were recruited. Based on mean changes in Movement Disorder Society Unified Parkinson’s Disease Rating Scale part 3 score and levodopa equivalent daily dosage, the participants were categorized into rapid progression, medium progression, and slow progression groups. Odors associated with the risk of PD motor progression were identified by calculating the odds ratios of UPSIT item identification between the rapid and slow progression groups. Receiver operating characteristic curve analysis of these odors was conducted to determine an optimal threshold for rapid motor progression. RESULTS: A total of 117 PD patients were screened for group classification. Preserved identification of neutral/pleasant odors including banana, peach, magnolia, and baby powder was significantly correlated with rapid motor progression. The risk of rapid progression increased with more detected risk odors. Detection of ≥1.5 risk odors could differentiate rapid progression from slow progression with a sensitivity of 85.7%, specificity of 45.8%, and area under the receiver operating characteristic curve of 0.687. CONCLUSION: Preserved identification of neutral/pleasant odors may help to predict PD motor progression, and detection of ≥1.5 UPSIT motor progression risk odors could improve the predictive power. In PD patients with a similar level of motor disability during initial screening, preserved pleasant/neutral odor identification may imply relatively better cortical odor discriminative function, which may suggest the body-first (caudo-rostral) subtype with faster disease progression. Frontiers Media S.A. 2023-10-23 /pmc/articles/PMC10625917/ /pubmed/37936914 http://dx.doi.org/10.3389/fneur.2023.1265549 Text en Copyright © 2023 Lin, Fang, Lei, Chiu, Chang and Guo. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neurology Lin, Yu-Hsuan Fang, Ting-Chun Lei, Hsin-Bei Chiu, Shih-Chi Chang, Ming-Hong Guo, Yi-Jen UPSIT subitems may predict motor progression in Parkinson’s disease |
title | UPSIT subitems may predict motor progression in Parkinson’s disease |
title_full | UPSIT subitems may predict motor progression in Parkinson’s disease |
title_fullStr | UPSIT subitems may predict motor progression in Parkinson’s disease |
title_full_unstemmed | UPSIT subitems may predict motor progression in Parkinson’s disease |
title_short | UPSIT subitems may predict motor progression in Parkinson’s disease |
title_sort | upsit subitems may predict motor progression in parkinson’s disease |
topic | Neurology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10625917/ https://www.ncbi.nlm.nih.gov/pubmed/37936914 http://dx.doi.org/10.3389/fneur.2023.1265549 |
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