Correlation between Triclosan (TCS) exposure and endometriosis

OBJECTIVE: To study the correlation of Triclosan (TCS) exposure with typing and staging of endometriosis, and with other potential influencing factors. METHODS: This was a retrospective study. Thirty two patients that were diagnosed with endometriosis by laparoscopy or surgery in Taicang First People’s Hospital from May 2020 to December 2021 were enrolled in the endometriosis group, and patients who were confirmed free of endometriosis by surgeries for other purposes during the same period were enrolled as the control group. All blood samples were tested twice in two different vials. The association of TCS exposure level with occurrence, staging, typing of endometriosis, and income of the patients were analyzed. RESULTS: Patients with endometriosis had significantly higher TCS exposure levels than the control group. TCS exposure level in patients with endometriosis was positively correlated with patient income), and was significantly higher in patients with Stage-IV endometriosis than in those with Stage-III and II diseases. TCS exposure levels showed no significant difference among patients with ovarian type, ovarian + peritoneal type, and deep nodular type endometriosis TCS exposure level in patients with endometriosis was positively correlated with the staging of the disease. TCS exposure was highly positively correlated with the staging of the disease in patients with ovarian type endometriosis and in patients with deep nodular endometriosis, but there’s no such correlation in patients with ovarian + peritoneal type endometriosis. CONCLUSION: TCS exposure level in endometriosis patients was higher than that in normal women, and is positively correlated with endometriosis staging and income of the patients.