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Influence of family history on penetrance of hereditary cancers in a population setting

BACKGROUND: We sought to investigate how penetrance of familial cancer syndromes varies with family history using a population-based cohort. METHODS: We analysed 454,712 UK Biobank participants with exome sequence and clinical data (data collected between March 2006 and June 2021). We identified par...

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Detalles Bibliográficos
Autores principales:	Jackson, Leigh, Weedon, Michael N., Green, Harry D., Mallabar-Rimmer, Bethan, Harrison, Jamie W., Wood, Andy R., Ruth, Kate S., Tyrrell, Jess, Wright, Caroline F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10626157/ https://www.ncbi.nlm.nih.gov/pubmed/37936660 http://dx.doi.org/10.1016/j.eclinm.2023.102159

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