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Chromosome-level genome editing uncovers aneuploidy addiction in cancer

Publishing in Science, Girish and colleagues achieve chromosome-level genome editing to reveal a requirement for aneuploidy in breast and melanoma cancers. Authors developed and leveraged ReDACT (restoring disomy in aneuploid cells using CRISPR targeting) to generate isogenic models of aneuploidy an...

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Detalles Bibliográficos
Autores principales:	O’Brien, Siobhan, Berger, Alice H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Spotlight
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10626219/ https://www.ncbi.nlm.nih.gov/pubmed/37820727 http://dx.doi.org/10.1016/j.crmeth.2023.100618

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