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Risk factors for prostate-specific antigen persistence in pT3aN0 prostate cancer after robot-assisted laparoscopic radical prostatectomy: a retrospective study
BACKGROUND: The aim of this study was to evaluate the risk factors for prostate-specific antigen (PSA) persistence in pathological stage T3aN0 prostate cancer (PCa) after robot-assisted laparoscopic radical prostatectomy (RALP). METHODS: A retrospective study was performed on 326 patients with pT3aN...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Journal of Yeungnam Medical Science
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10626309/ https://www.ncbi.nlm.nih.gov/pubmed/37376735 http://dx.doi.org/10.12701/jyms.2023.00234 |
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author | Kim, Jun Seop Chung, Jae Hoon Song, Wan Kang, Minyong Sung, Hyun Hwan Jeon, Hwang Gyun Jeong, Byong Change Seo, Seong Il Lee, Hyun Moo Jeon, Seong Soo |
author_facet | Kim, Jun Seop Chung, Jae Hoon Song, Wan Kang, Minyong Sung, Hyun Hwan Jeon, Hwang Gyun Jeong, Byong Change Seo, Seong Il Lee, Hyun Moo Jeon, Seong Soo |
author_sort | Kim, Jun Seop |
collection | PubMed |
description | BACKGROUND: The aim of this study was to evaluate the risk factors for prostate-specific antigen (PSA) persistence in pathological stage T3aN0 prostate cancer (PCa) after robot-assisted laparoscopic radical prostatectomy (RALP). METHODS: A retrospective study was performed on 326 patients with pT3aN0 PCa who underwent RALP between March 2020 and February 2022. PSA persistence was defined as nadir PSA of >0.1 ng/mL after RALP, and the risk factors for PSA persistence were evaluated using logistic regression analysis. RESULTS: Among 326 patients, 61 (18.71%) had PSA persistence and 265 (81.29%) had PSA of <0.1 ng/mL after RALP (successful radical prostatectomy [RP] group). In the PSA persistence group, 51 patients (83.61%) received adjuvant treatment. Biochemical recurrence occurred in 27 patients (10.19%) in the successful RP group during the mean follow-up period of 15.22 months. Multivariate analysis showed that the risk factors for PSA persistence were large prostate volume (hazard ratio [HR], 1.017; 95% confidence interval [CI], 1.002–1.036; p=0.046), lymphovascular invasion (LVI) (HR, 2.605; 95% CI, 1.022–6.643; p=0.045), and surgical margin involvement (HR, 2.220; 95% CI, 1.110–4.438; p=0.024). CONCLUSION: Adjuvant treatment may be needed for improved prognosis in patients with pT3aN0 PCa after RALP with a large prostate size, LVI, or surgical margin involvement. |
format | Online Article Text |
id | pubmed-10626309 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Journal of Yeungnam Medical Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-106263092023-11-07 Risk factors for prostate-specific antigen persistence in pT3aN0 prostate cancer after robot-assisted laparoscopic radical prostatectomy: a retrospective study Kim, Jun Seop Chung, Jae Hoon Song, Wan Kang, Minyong Sung, Hyun Hwan Jeon, Hwang Gyun Jeong, Byong Change Seo, Seong Il Lee, Hyun Moo Jeon, Seong Soo J Yeungnam Med Sci Original Article BACKGROUND: The aim of this study was to evaluate the risk factors for prostate-specific antigen (PSA) persistence in pathological stage T3aN0 prostate cancer (PCa) after robot-assisted laparoscopic radical prostatectomy (RALP). METHODS: A retrospective study was performed on 326 patients with pT3aN0 PCa who underwent RALP between March 2020 and February 2022. PSA persistence was defined as nadir PSA of >0.1 ng/mL after RALP, and the risk factors for PSA persistence were evaluated using logistic regression analysis. RESULTS: Among 326 patients, 61 (18.71%) had PSA persistence and 265 (81.29%) had PSA of <0.1 ng/mL after RALP (successful radical prostatectomy [RP] group). In the PSA persistence group, 51 patients (83.61%) received adjuvant treatment. Biochemical recurrence occurred in 27 patients (10.19%) in the successful RP group during the mean follow-up period of 15.22 months. Multivariate analysis showed that the risk factors for PSA persistence were large prostate volume (hazard ratio [HR], 1.017; 95% confidence interval [CI], 1.002–1.036; p=0.046), lymphovascular invasion (LVI) (HR, 2.605; 95% CI, 1.022–6.643; p=0.045), and surgical margin involvement (HR, 2.220; 95% CI, 1.110–4.438; p=0.024). CONCLUSION: Adjuvant treatment may be needed for improved prognosis in patients with pT3aN0 PCa after RALP with a large prostate size, LVI, or surgical margin involvement. Journal of Yeungnam Medical Science 2023-06-28 /pmc/articles/PMC10626309/ /pubmed/37376735 http://dx.doi.org/10.12701/jyms.2023.00234 Text en Copyright © 2023 Yeungnam University College of Medicine, Yeungnam University Institute of Medical Science https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Kim, Jun Seop Chung, Jae Hoon Song, Wan Kang, Minyong Sung, Hyun Hwan Jeon, Hwang Gyun Jeong, Byong Change Seo, Seong Il Lee, Hyun Moo Jeon, Seong Soo Risk factors for prostate-specific antigen persistence in pT3aN0 prostate cancer after robot-assisted laparoscopic radical prostatectomy: a retrospective study |
title | Risk factors for prostate-specific antigen persistence in pT3aN0 prostate cancer after robot-assisted laparoscopic radical prostatectomy: a retrospective study |
title_full | Risk factors for prostate-specific antigen persistence in pT3aN0 prostate cancer after robot-assisted laparoscopic radical prostatectomy: a retrospective study |
title_fullStr | Risk factors for prostate-specific antigen persistence in pT3aN0 prostate cancer after robot-assisted laparoscopic radical prostatectomy: a retrospective study |
title_full_unstemmed | Risk factors for prostate-specific antigen persistence in pT3aN0 prostate cancer after robot-assisted laparoscopic radical prostatectomy: a retrospective study |
title_short | Risk factors for prostate-specific antigen persistence in pT3aN0 prostate cancer after robot-assisted laparoscopic radical prostatectomy: a retrospective study |
title_sort | risk factors for prostate-specific antigen persistence in pt3an0 prostate cancer after robot-assisted laparoscopic radical prostatectomy: a retrospective study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10626309/ https://www.ncbi.nlm.nih.gov/pubmed/37376735 http://dx.doi.org/10.12701/jyms.2023.00234 |
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