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Risk factors associated with low anterior resection syndrome: a cross-sectional study

PURPOSE: Oncological outcomes following rectal cancer surgery have improved significantly over recent decades with lower recurrences and longer overall survival. However, many of the patients experienced low anterior resection syndrome (LARS). This study identified the prevalence and risk factors as...

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Autores principales: Lim, See Liang, Wan Zain, Wan Zainira, Zahari, Zalina, Zakaria, Andee Dzulkarnaen, Hashim, Mohd Nizam Md, Wong, Michael Pak-Kai, Zakaria, Zaidi, Ramely, Rosnelifaizur, Sidek, Ahmad Shanwani Mohamed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society of Coloproctology 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10626329/
https://www.ncbi.nlm.nih.gov/pubmed/35655395
http://dx.doi.org/10.3393/ac.2022.00227.0032
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author Lim, See Liang
Wan Zain, Wan Zainira
Zahari, Zalina
Zakaria, Andee Dzulkarnaen
Hashim, Mohd Nizam Md
Wong, Michael Pak-Kai
Zakaria, Zaidi
Ramely, Rosnelifaizur
Sidek, Ahmad Shanwani Mohamed
author_facet Lim, See Liang
Wan Zain, Wan Zainira
Zahari, Zalina
Zakaria, Andee Dzulkarnaen
Hashim, Mohd Nizam Md
Wong, Michael Pak-Kai
Zakaria, Zaidi
Ramely, Rosnelifaizur
Sidek, Ahmad Shanwani Mohamed
author_sort Lim, See Liang
collection PubMed
description PURPOSE: Oncological outcomes following rectal cancer surgery have improved significantly over recent decades with lower recurrences and longer overall survival. However, many of the patients experienced low anterior resection syndrome (LARS). This study identified the prevalence and risk factors associated with the development of LARS. METHODS: This cross-sectional study involved patients who were diagnosed with rectal cancer and had undergone sphincter-preserving low anterior resection from January 2011 to December 2020. Upon clinic follow-up, patients were asked to complete an interviewed based questionnaire (LARS score) designed to assess bowel dysfunction after rectal cancer surgery. RESULTS: Out of 76 patients, 25 patients (32.9%) had major LARS, 10 patients (13.2%) had minor LARS, and 41 patients (53.9%) had no LARS. The height of tumor from anal verge showed an association with the development of major LARS (P=0.039). Those patients with less than 8 cm tumor from anal verge had an increased risk of LARS by 3 times compared to those with 8 cm and above (adjusted odds ratio, 3.11; 95% confidence interval, 1.06–9.13). CONCLUSION: Results from our study show that low tumor height was a significant risk factor that has a negative impact on bowel function after surgery. The high prevalence of LARS emphasizes the need for study regarding risk factors and the importance of understanding the pathophysiology of LARS, in order for us to improve patient bowel function and quality of life after rectal cancer surgery.
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spelling pubmed-106263292023-11-07 Risk factors associated with low anterior resection syndrome: a cross-sectional study Lim, See Liang Wan Zain, Wan Zainira Zahari, Zalina Zakaria, Andee Dzulkarnaen Hashim, Mohd Nizam Md Wong, Michael Pak-Kai Zakaria, Zaidi Ramely, Rosnelifaizur Sidek, Ahmad Shanwani Mohamed Ann Coloproctol Original Article PURPOSE: Oncological outcomes following rectal cancer surgery have improved significantly over recent decades with lower recurrences and longer overall survival. However, many of the patients experienced low anterior resection syndrome (LARS). This study identified the prevalence and risk factors associated with the development of LARS. METHODS: This cross-sectional study involved patients who were diagnosed with rectal cancer and had undergone sphincter-preserving low anterior resection from January 2011 to December 2020. Upon clinic follow-up, patients were asked to complete an interviewed based questionnaire (LARS score) designed to assess bowel dysfunction after rectal cancer surgery. RESULTS: Out of 76 patients, 25 patients (32.9%) had major LARS, 10 patients (13.2%) had minor LARS, and 41 patients (53.9%) had no LARS. The height of tumor from anal verge showed an association with the development of major LARS (P=0.039). Those patients with less than 8 cm tumor from anal verge had an increased risk of LARS by 3 times compared to those with 8 cm and above (adjusted odds ratio, 3.11; 95% confidence interval, 1.06–9.13). CONCLUSION: Results from our study show that low tumor height was a significant risk factor that has a negative impact on bowel function after surgery. The high prevalence of LARS emphasizes the need for study regarding risk factors and the importance of understanding the pathophysiology of LARS, in order for us to improve patient bowel function and quality of life after rectal cancer surgery. Korean Society of Coloproctology 2023-10 2022-06-03 /pmc/articles/PMC10626329/ /pubmed/35655395 http://dx.doi.org/10.3393/ac.2022.00227.0032 Text en Copyright © 2023 The Korean Society of Coloproctology https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Lim, See Liang
Wan Zain, Wan Zainira
Zahari, Zalina
Zakaria, Andee Dzulkarnaen
Hashim, Mohd Nizam Md
Wong, Michael Pak-Kai
Zakaria, Zaidi
Ramely, Rosnelifaizur
Sidek, Ahmad Shanwani Mohamed
Risk factors associated with low anterior resection syndrome: a cross-sectional study
title Risk factors associated with low anterior resection syndrome: a cross-sectional study
title_full Risk factors associated with low anterior resection syndrome: a cross-sectional study
title_fullStr Risk factors associated with low anterior resection syndrome: a cross-sectional study
title_full_unstemmed Risk factors associated with low anterior resection syndrome: a cross-sectional study
title_short Risk factors associated with low anterior resection syndrome: a cross-sectional study
title_sort risk factors associated with low anterior resection syndrome: a cross-sectional study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10626329/
https://www.ncbi.nlm.nih.gov/pubmed/35655395
http://dx.doi.org/10.3393/ac.2022.00227.0032
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