Enhancement of apixaban's solubility and dissolution rate by inclusion complex (β-cyclodextrin and hydroxypropyl β-cyclodextrin) and computational calculation of their inclusion complexes

BACKGROUND AND PURPOSE: Apixaban (AP) is a factor X inhibitor, an orally active drug that inhibits blood coagulation for better prevention of venous thromboembolism. It has poor solubility, dissolution rate and low bioavailability. The aim of this study was to improve the aqueous solubility and diss...

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Detalles Bibliográficos
Autores principales: Salman, Zainab N., Al-Ani, Israa, Al Azzam, Khaldun M., Majeed, Bashar J. M., Abdallah, Hassan H., Negim, El-Sayed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Association of Physical Chemists 2023
Materias:
Original Scientific Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10626519/
https://www.ncbi.nlm.nih.gov/pubmed/37937243
http://dx.doi.org/10.5599/admet.1885

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10626519/
https://www.ncbi.nlm.nih.gov/pubmed/37937243
http://dx.doi.org/10.5599/admet.1885

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