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The influence of physiological and pathological perturbations on blood-brain barrier function

The blood-brain barrier (BBB) is located at the interface between the vascular system and the brain parenchyma, and is responsible for communication with systemic circulation and peripheral tissues. During life, the BBB can be subjected to a wide range of perturbations or stresses that may be endoge...

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Autores principales: Zhao, Nan, Chung, Tracy D., Guo, Zhaobin, Jamieson, John J., Liang, Lily, Linville, Raleigh M., Pessell, Alex F., Wang, Linus, Searson, Peter C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10626523/
https://www.ncbi.nlm.nih.gov/pubmed/37937070
http://dx.doi.org/10.3389/fnins.2023.1289894
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author Zhao, Nan
Chung, Tracy D.
Guo, Zhaobin
Jamieson, John J.
Liang, Lily
Linville, Raleigh M.
Pessell, Alex F.
Wang, Linus
Searson, Peter C.
author_facet Zhao, Nan
Chung, Tracy D.
Guo, Zhaobin
Jamieson, John J.
Liang, Lily
Linville, Raleigh M.
Pessell, Alex F.
Wang, Linus
Searson, Peter C.
author_sort Zhao, Nan
collection PubMed
description The blood-brain barrier (BBB) is located at the interface between the vascular system and the brain parenchyma, and is responsible for communication with systemic circulation and peripheral tissues. During life, the BBB can be subjected to a wide range of perturbations or stresses that may be endogenous or exogenous, pathological or therapeutic, or intended or unintended. The risk factors for many diseases of the brain are multifactorial and involve perturbations that may occur simultaneously (e.g., two-hit model for Alzheimer’s disease) and result in different outcomes. Therefore, it is important to understand the influence of individual perturbations on BBB function in isolation. Here we review the effects of eight perturbations: mechanical forces, temperature, electromagnetic radiation, hypoxia, endogenous factors, exogenous factors, chemical factors, and pathogens. While some perturbations may result in acute or chronic BBB disruption, many are also exploited for diagnostic or therapeutic purposes. The resultant outcome on BBB function depends on the dose (or magnitude) and duration of the perturbation. Homeostasis may be restored by self-repair, for example, via processes such as proliferation of affected cells or angiogenesis to create new vasculature. Transient or sustained BBB dysfunction may result in acute or pathological symptoms, for example, microhemorrhages or hypoperfusion. In more extreme cases, perturbations may lead to cytotoxicity and cell death, for example, through exposure to cytotoxic plaques.
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spelling pubmed-106265232023-11-07 The influence of physiological and pathological perturbations on blood-brain barrier function Zhao, Nan Chung, Tracy D. Guo, Zhaobin Jamieson, John J. Liang, Lily Linville, Raleigh M. Pessell, Alex F. Wang, Linus Searson, Peter C. Front Neurosci Neuroscience The blood-brain barrier (BBB) is located at the interface between the vascular system and the brain parenchyma, and is responsible for communication with systemic circulation and peripheral tissues. During life, the BBB can be subjected to a wide range of perturbations or stresses that may be endogenous or exogenous, pathological or therapeutic, or intended or unintended. The risk factors for many diseases of the brain are multifactorial and involve perturbations that may occur simultaneously (e.g., two-hit model for Alzheimer’s disease) and result in different outcomes. Therefore, it is important to understand the influence of individual perturbations on BBB function in isolation. Here we review the effects of eight perturbations: mechanical forces, temperature, electromagnetic radiation, hypoxia, endogenous factors, exogenous factors, chemical factors, and pathogens. While some perturbations may result in acute or chronic BBB disruption, many are also exploited for diagnostic or therapeutic purposes. The resultant outcome on BBB function depends on the dose (or magnitude) and duration of the perturbation. Homeostasis may be restored by self-repair, for example, via processes such as proliferation of affected cells or angiogenesis to create new vasculature. Transient or sustained BBB dysfunction may result in acute or pathological symptoms, for example, microhemorrhages or hypoperfusion. In more extreme cases, perturbations may lead to cytotoxicity and cell death, for example, through exposure to cytotoxic plaques. Frontiers Media S.A. 2023-10-23 /pmc/articles/PMC10626523/ /pubmed/37937070 http://dx.doi.org/10.3389/fnins.2023.1289894 Text en Copyright © 2023 Zhao, Chung, Guo, Jamieson, Liang, Linville, Pessell, Wang and Searson. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Zhao, Nan
Chung, Tracy D.
Guo, Zhaobin
Jamieson, John J.
Liang, Lily
Linville, Raleigh M.
Pessell, Alex F.
Wang, Linus
Searson, Peter C.
The influence of physiological and pathological perturbations on blood-brain barrier function
title The influence of physiological and pathological perturbations on blood-brain barrier function
title_full The influence of physiological and pathological perturbations on blood-brain barrier function
title_fullStr The influence of physiological and pathological perturbations on blood-brain barrier function
title_full_unstemmed The influence of physiological and pathological perturbations on blood-brain barrier function
title_short The influence of physiological and pathological perturbations on blood-brain barrier function
title_sort influence of physiological and pathological perturbations on blood-brain barrier function
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10626523/
https://www.ncbi.nlm.nih.gov/pubmed/37937070
http://dx.doi.org/10.3389/fnins.2023.1289894
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