Cargando…

Design, synthesis and antiproliferative screening of newly synthesized coumarin-acrylamide hybrids as potential cytotoxic and apoptosis inducing agents

On the basis of the observed biological activity of coumarin and acrylamide derivatives, a new set of coumarin-acrylamide-CA-4 hybrids was designed and synthesized. These compounds were investigated for their cytotoxic activity against cancerous human liver cell line HepG2 cells using 5-fluorouracil...

Descripción completa

Detalles Bibliográficos
Autores principales:	Abd El-Lateef, Hany M., Abdel Ghany, Lina M. A., Saleem, Rasha Mohammed, Ahmed Maghrabi, Ali Hassan, Yahya Alahdal, Maryam Abdulrahman, Khalifa Ali, Eman Hussain, Beshay, Botros Y., Zaki, Islam, Masoud, Reham E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2023
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10626558/ https://www.ncbi.nlm.nih.gov/pubmed/37936638 http://dx.doi.org/10.1039/d3ra06644d

Ejemplares similares

Design, synthesis, anti-inflammatory evaluation, and molecular modelling of new coumarin-based analogs combined curcumin and other heterocycles as potential TNF-α production inhibitors via upregulating Nrf2/HO-1, downregulating AKT/mTOR signalling pathways and downregulating NF-κB in LPS induced macrophages
por: Ghany, Lina M. A. Abdel, et al.
Publicado: (2023)

Novel Acrylate-Based Derivatives: Design, Synthesis, Antiproliferative Screening, and Docking Study as Potential Combretastatin Analogues
por: Fayad, Eman, et al.
Publicado: (2023)

Design and synthesis of new trimethoxylphenyl-linked combretastatin analogues loaded on diamond nanoparticles as a panel for ameliorated solubility and antiproliferative activity
por: Zaki, Islam, et al.
Publicado: (2022)

Design, synthesis and antiproliferative screening of newly synthesized acrylate derivatives as potential anticancer agents
por: Alshaya, Dalal Sulaiman, et al.
Publicado: (2023)

Design and Synthesis of Newly Synthesized Acrylamide Derivatives as Potential Chemotherapeutic Agents against MCF-7 Breast Cancer Cell Line Lodged on PEGylated Bilosomal Nano-Vesicles for Improving Cytotoxic Activity
por: Zaki, Islam, et al.
Publicado: (2021)

Synthesis and Antiproliferative Effect of Halogenated Coumarin Derivatives
por: Dettori, Tinuccia, et al.
Publicado: (2022)

Synthesis of Structurally Related Coumarin Derivatives as Antiproliferative Agents
por: Bruna-Haupt, Ezequiel F., et al.
Publicado: (2023)

Evaluation of the Antioxidant Capacity of Synthesized Coumarins
por: Vianna, Damiana R., et al.
Publicado: (2012)

Antiproliferative evaluation of terpenoids and terpenoid coumarins from Ferulago macrocarpa (Fenzl) Boiss. fruits
por: Sajjadi, Seyed-Ebrahim, et al.
Publicado: (2015)

Antiproliferative Scalarane-Based Metabolites from the Red Sea Sponge Hyrtios erectus
por: Elhady, Sameh S., et al.
Publicado: (2016)

Antimicrobial activity of novel synthesized coumarin based transitional metal complexes
por: Sahoo, Jyotirmaya, et al.
Publicado: (2016)

Hydrogen Peroxide Scavenging Activity of Novel Coumarins Synthesized Using Different Approaches
por: Al-Amiery, Ahmed A., et al.
Publicado: (2015)

Green Synthesized Zinc Oxide Nanoparticles Using Moringa olifera Ethanolic Extract Lessens Acrylamide-Induced Testicular Damage, Apoptosis, and Steroidogenesis-Related Gene Dysregulation in Adult Rats
por: Mostafa-Hedeab, Gomaa, et al.
Publicado: (2023)

EGFR and PI3K/m-TOR inhibitors: design, microwave assisted synthesis and anticancer activity of thiazole–coumarin hybrids
por: Batran, Rasha Z., et al.
Publicado: (2023)

Design, Synthesis, Docking Study, and Antiproliferative Evaluation of Novel Schiff Base–Benzimidazole Hybrids with VEGFR-2 Inhibitory Activity
por: Abd El-Lateef, Hany M., et al.
Publicado: (2023)

The variation in the self-perceived quality of life and health care amongst smokers, passive smokers, ex-smokers and non-smokers in Canada
por: Beshay, Samy, et al.
Publicado: (2015)

Computational and biological studies of novel thiazolyl coumarin derivatives synthesized through Suzuki coupling
por: PARVEEN, Shaista, et al.
Publicado: (2020)

Syntheses of Minutuminolate and Related Coumarin Natural Products and Evaluation of Their TNF-α Inhibitory Activities
por: Choo, Malcolm Zheng Yuan, et al.
Publicado: (2023)

New Samarium(III), Gadolinium(III), and Dysprosium(III) Complexes of Coumarin-3-Carboxylic Acid as Antiproliferative Agents
por: Kostova, Irena, et al.
Publicado: (2007)

‘Poly phenolic phytoceutical loaded nano-bilosomes for enhanced caco-2 cell permeability and SARS-CoV 2 antiviral activity’: in-vitro and insilico studies
por: Zakaria, Mohamed Y., et al.
Publicado: (2023)

Design and Synthesis of 2-(4-Bromophenyl)Quinoline-4-Carbohydrazide Derivatives via Molecular Hybridization as Novel Microbial DNA-Gyrase Inhibitors
por: Abd El-Lateef, Hany M., et al.
Publicado: (2023)

Design, Synthesis, and Antiproliferative Evaluation of Novel Coumarin/2-Cyanoacryloyl Hybrids as Apoptosis Inducing Agents by Activation of Caspase-Dependent Pathway
por: Zhang, Yu-Ying, et al.
Publicado: (2018)

Coumarins and Coumarin-Related Compounds in Pharmacotherapy of Cancer
por: Küpeli Akkol, Esra, et al.
Publicado: (2020)

Antiproliferative Properties of Newly Synthesized 19-Nortestosterone Analogs Without Substantial Androgenic Activity
por: Gyovai, András, et al.
Publicado: (2018)

Antimicrobial and Antiproliferative Activity of Green Synthesized Silver Nanoparticles Using Bee Bread Extracts
por: Urcan, Adriana Cristina, et al.
Publicado: (2023)

Morphology Control and Metallization of Porous Polymers Synthesized by Michael Addition Reactions of a Multi-Functional Acrylamide with a Diamine
por: Naga, Naofumi, et al.
Publicado: (2021)

Therapeutic potential of coumarins as antiviral agents
por: Hassan, Mohd. Zaheen, et al.
Publicado: (2016)

Reproductive toxicology. Acrylamide.
Publicado: (1997)

Assessment of the genotoxicity of acrylamide
por: Benford, Diane, et al.
Publicado: (2022)

An investigation on 3-acetyl-7-methoxy-coumarin Schiff bases and their Ru(ii) metallates with potent antiproliferative activity and enhanced LDH and NO release
por: Kalaiarasi, G., et al.
Publicado: (2018)

Structure-based tailoring of the first coumarins-specific bergaptol O-methyltransferase to synthesize bergapten for depigmentation disorder treatment
por: Zhao, Yucheng, et al.
Publicado: (2019)

Development of a New Methodology for Dearomative Borylation of Coumarins and Chromenes and Its Applications to Synthesize Boron-Containing Retinoids
por: Das, Bhaskar C., et al.
Publicado: (2023)

Simultaneous mitigation of 4(5)‐methylimidazole, acrylamide, and 5‐hydroxymethylfurfural in ammonia biscuits by supplementing with food hydrocolloids
por: Mousa, Rasha M. A.
Publicado: (2019)

Antibacterial, Antiproliferative, and Immunomodulatory Activity of Silver Nanoparticles Synthesized with Fucans from the Alga Dictyota mertensii
por: Fernandes-Negreiros, Marília Medeiros, et al.
Publicado: (2017)

Daphnetin: A bioactive natural coumarin with diverse therapeutic potentials
por: Javed, Maira, et al.
Publicado: (2022)

Assessment of cytotoxicity of (N-isopropyl acrylamide) and Poly(N-isopropyl acrylamide)-coated surfaces
por: Cooperstein, Marta A, et al.
Publicado: (2013)

Soy Protein Isolate Interacted with Acrylamide to Reduce the Release of Acrylamide in the In Vitro Digestion Model
por: Shen, Yu, et al.
Publicado: (2023)

Esculetin, a coumarin derivative, exerts in vitro and in vivo antiproliferative activity against hepatocellular carcinoma by initiating a mitochondrial-dependent apoptosis pathway
por: Wang, J., et al.
Publicado: (2014)

Biological activities and biosorption potential of red algae (Corallina officinalis) to remove toxic malachite green dye
por: Youssef, Elen Emad, et al.
Publicado: (2023)

Synthesis and Biological Activity Screening of Newly Synthesized Trimethoxyphenyl-Based Analogues as Potential Anticancer Agents
por: Al-Warhi, Tarfah, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_bpljfg1embiogrn6ej960o9s0d