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Homologous recombination deficiency (HRD) testing on cell-free tumor DNA from peritoneal fluid

BACKGROUND: Knowing the homologous recombination deficiency (HRD) status in advanced epithelial ovarian cancer (EOC) is vital for patient management. HRD is determined by BRCA1/BRCA2 pathogenic variants or genomic instability. However, tumor DNA analysis is inconclusive in 15–19% of cases. Peritonea...

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Detalles Bibliográficos
Autores principales:	Roussel-Simonin, Cyril, Blanc-Durand, Felix, Tang, Roseline, Vasseur, Damien, Le Formal, Audrey, Chardin, Laure, Yaniz, Elisa, Gouy, Sébastien, Maulard, Amandine, Scherier, Stéphanie, Sanson, Claire, Lacroix, Ludovic, Cotteret, Sophie, Mauny, Lea, Zaccarini, François, Rouleau, Etienne, Leary, Alexandra
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10626673/ https://www.ncbi.nlm.nih.gov/pubmed/37932736 http://dx.doi.org/10.1186/s12943-023-01864-1

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