Th17-inducing dendritic cell vaccines stimulate effective CD4 T cell-dependent antitumor immunity in ovarian cancer that overcomes resistance to immune checkpoint blockade

BACKGROUND: Ovarian cancer (OC), a highly lethal cancer in women, has a 48% 5-year overall survival rate. Prior studies link the presence of IL-17 and Th17 T cells in the tumor microenvironment to improved survival in OC patients. To determine if Th17-inducing vaccines are therapeutically effective...

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Detalles Bibliográficos
Autores principales: Luo, Yan, Shreeder, Barath, Jenkins, James W, Shi, Huashan, Lamichhane, Purushottam, Zhou, Kexun, Bahr, Deborah A, Kurian, Sophia, Jones, Katherine A, Daum, Joshua I, Dutta, Navnita, Necela, Brian M, Cannon, Martin J, Block, Matthew S, Knutson, Keith L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Clinical/Translational Cancer Immunotherapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10626769/
https://www.ncbi.nlm.nih.gov/pubmed/37918918
http://dx.doi.org/10.1136/jitc-2023-007661

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10626769/
https://www.ncbi.nlm.nih.gov/pubmed/37918918
http://dx.doi.org/10.1136/jitc-2023-007661

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