Intraperitoneal administration of a modified vaccinia virus Ankara confers single-chain interleukin-12 expression to the omentum and achieves immune-mediated efficacy against peritoneal carcinomatosis

BACKGROUND: Peritoneal carcinomatosis is an advanced stage of cancer in which the disease has spread to the peritoneal cavity. In order to restore antitumor immunity subverted by tumor cells in this location, we evaluated intraperitoneal administrations of modified vaccinia virus Ankara (MVA) engine...

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Detalles Bibliográficos
Autores principales: Bella, Ángela, Arrizabalaga, Leire, Di Trani, Claudia Augusta, Gonzalez-Gomariz, Jose, Gomar, Celia, Russo-Cabrera, Joan Salvador, Olivera, Irene, Cirella, Assunta, Fernandez-Sendin, Myriam, Alvarez, Maite, Teijeira, Alvaro, Atay, Cigdem, Medina-Echeverz, José, Hinterberger, Maria, Hochrein, Hubertus, Melero, Ignacio, Berraondo, Pedro, Aranda, Fernando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Oncolytic and Local Immunotherapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10626836/
https://www.ncbi.nlm.nih.gov/pubmed/37918917
http://dx.doi.org/10.1136/jitc-2023-006702

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