2-[4-(2-Chloro­benz­yl)-3-methyl-6-oxo-1,6-di­hydro­pyridazin-1-yl]-N-(4-fluoro­phen­yl)acetamide

The conformation of the title mol­ecule, C(20)H(17)ClFN(3)O(2), is partly determined by an intra­molecular C—H⋯O hydrogen bond, which leads to a dihedral angle of 14.7 (4)° between the fluoro­benzene ring and the acetamide group. The 2-chloro­benzyl group is rotationally disordered over two orientat...

Descripción completa

Detalles Bibliográficos
Autores principales: Assila, Hamza, Ameziane El Hassani, Issam, El Moutaouakil Ala Allah, Abderrazzak, Alsubari, Abdulsalam, Mague, Joel T, Ramli, Youssef, Ansar, MHammed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2023
Materias:
Data Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10626847/
https://www.ncbi.nlm.nih.gov/pubmed/37936589
http://dx.doi.org/10.1107/S241431462300901X
_version_ 1785131425981267968
author Assila, Hamza
Ameziane El Hassani, Issam
El Moutaouakil Ala Allah, Abderrazzak
Alsubari, Abdulsalam
Mague, Joel T
Ramli, Youssef
Ansar, MHammed
author_facet Assila, Hamza
Ameziane El Hassani, Issam
El Moutaouakil Ala Allah, Abderrazzak
Alsubari, Abdulsalam
Mague, Joel T
Ramli, Youssef
Ansar, MHammed
author_sort Assila, Hamza
collection PubMed
description The conformation of the title mol­ecule, C(20)H(17)ClFN(3)O(2), is partly determined by an intra­molecular C—H⋯O hydrogen bond, which leads to a dihedral angle of 14.7 (4)° between the fluoro­benzene ring and the acetamide group. The 2-chloro­benzyl group is rotationally disordered over two orientations in a 0.656 (2): 0.344 (2) ratio. In the crystal, a layered structure is formed by N—H⋯O, C—H⋯O and C—H⋯F hydrogen bonds plus slipped π–π stacking inter­actions. [Image: see text]
format Online
Article
Text
id pubmed-10626847
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher International Union of Crystallography
record_format MEDLINE/PubMed
spelling pubmed-106268472023-11-07 2-[4-(2-Chloro­benz­yl)-3-methyl-6-oxo-1,6-di­hydro­pyridazin-1-yl]-N-(4-fluoro­phen­yl)acetamide Assila, Hamza Ameziane El Hassani, Issam El Moutaouakil Ala Allah, Abderrazzak Alsubari, Abdulsalam Mague, Joel T Ramli, Youssef Ansar, MHammed IUCrdata Data Reports The conformation of the title mol­ecule, C(20)H(17)ClFN(3)O(2), is partly determined by an intra­molecular C—H⋯O hydrogen bond, which leads to a dihedral angle of 14.7 (4)° between the fluoro­benzene ring and the acetamide group. The 2-chloro­benzyl group is rotationally disordered over two orientations in a 0.656 (2): 0.344 (2) ratio. In the crystal, a layered structure is formed by N—H⋯O, C—H⋯O and C—H⋯F hydrogen bonds plus slipped π–π stacking inter­actions. [Image: see text] International Union of Crystallography 2023-10-19 /pmc/articles/PMC10626847/ /pubmed/37936589 http://dx.doi.org/10.1107/S241431462300901X Text en © Assila et al. 2023 https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution (CC-BY) Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
spellingShingle Data Reports
Assila, Hamza
Ameziane El Hassani, Issam
El Moutaouakil Ala Allah, Abderrazzak
Alsubari, Abdulsalam
Mague, Joel T
Ramli, Youssef
Ansar, MHammed
2-[4-(2-Chloro­benz­yl)-3-methyl-6-oxo-1,6-di­hydro­pyridazin-1-yl]-N-(4-fluoro­phen­yl)acetamide
title 2-[4-(2-Chloro­benz­yl)-3-methyl-6-oxo-1,6-di­hydro­pyridazin-1-yl]-N-(4-fluoro­phen­yl)acetamide
title_full 2-[4-(2-Chloro­benz­yl)-3-methyl-6-oxo-1,6-di­hydro­pyridazin-1-yl]-N-(4-fluoro­phen­yl)acetamide
title_fullStr 2-[4-(2-Chloro­benz­yl)-3-methyl-6-oxo-1,6-di­hydro­pyridazin-1-yl]-N-(4-fluoro­phen­yl)acetamide
title_full_unstemmed 2-[4-(2-Chloro­benz­yl)-3-methyl-6-oxo-1,6-di­hydro­pyridazin-1-yl]-N-(4-fluoro­phen­yl)acetamide
title_short 2-[4-(2-Chloro­benz­yl)-3-methyl-6-oxo-1,6-di­hydro­pyridazin-1-yl]-N-(4-fluoro­phen­yl)acetamide
title_sort 2-[4-(2-chloro­benz­yl)-3-methyl-6-oxo-1,6-di­hydro­pyridazin-1-yl]-n-(4-fluoro­phen­yl)acetamide
topic Data Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10626847/
https://www.ncbi.nlm.nih.gov/pubmed/37936589
http://dx.doi.org/10.1107/S241431462300901X
work_keys_str_mv AT assilahamza 242chlorobenzyl3methyl6oxo16dihydropyridazin1yln4fluorophenylacetamide
AT amezianeelhassaniissam 242chlorobenzyl3methyl6oxo16dihydropyridazin1yln4fluorophenylacetamide
AT elmoutaouakilalaallahabderrazzak 242chlorobenzyl3methyl6oxo16dihydropyridazin1yln4fluorophenylacetamide
AT alsubariabdulsalam 242chlorobenzyl3methyl6oxo16dihydropyridazin1yln4fluorophenylacetamide
AT maguejoelt 242chlorobenzyl3methyl6oxo16dihydropyridazin1yln4fluorophenylacetamide
AT ramliyoussef 242chlorobenzyl3methyl6oxo16dihydropyridazin1yln4fluorophenylacetamide
AT ansarmhammed 242chlorobenzyl3methyl6oxo16dihydropyridazin1yln4fluorophenylacetamide

Ejemplares similares