Synthesis, crystal structure and in vitro anti-proliferative activity of 2-[(4-acetyl­phen­yl)carbamo­yl]phenyl acetate

2-[(4-Acetyl­phen­yl)carbamo­yl]phenyl acetate, C(17)H(15)NO(4), has been synthesized and structurally characterized. In the structure, N—H⋯O hydrogen-bonding inter­actions form chains of mol­ecules aligned along the [101] direction. The chains are linked by π–π and C—H⋯π inter­actions, forming a th...

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Autores principales: Mohamed-Ezzat, Reham A., Kariuki, Benson M., Srour, Aladdin M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2023
Materias:
Research Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10626967/
https://www.ncbi.nlm.nih.gov/pubmed/37936857
http://dx.doi.org/10.1107/S2056989023008526
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author Mohamed-Ezzat, Reham A.
Kariuki, Benson M.
Srour, Aladdin M.
author_facet Mohamed-Ezzat, Reham A.
Kariuki, Benson M.
Srour, Aladdin M.
author_sort Mohamed-Ezzat, Reham A.
collection PubMed
description 2-[(4-Acetyl­phen­yl)carbamo­yl]phenyl acetate, C(17)H(15)NO(4), has been synthesized and structurally characterized. In the structure, N—H⋯O hydrogen-bonding inter­actions form chains of mol­ecules aligned along the [101] direction. The chains are linked by π–π and C—H⋯π inter­actions, forming a three dimensional network. The compound has been screened for in vitro anti-proliferative activity revealing considerable activity.
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spelling pubmed-106269672023-11-07 Synthesis, crystal structure and in vitro anti-proliferative activity of 2-[(4-acetyl­phen­yl)carbamo­yl]phenyl acetate Mohamed-Ezzat, Reham A. Kariuki, Benson M. Srour, Aladdin M. Acta Crystallogr E Crystallogr Commun Research Communications 2-[(4-Acetyl­phen­yl)carbamo­yl]phenyl acetate, C(17)H(15)NO(4), has been synthesized and structurally characterized. In the structure, N—H⋯O hydrogen-bonding inter­actions form chains of mol­ecules aligned along the [101] direction. The chains are linked by π–π and C—H⋯π inter­actions, forming a three dimensional network. The compound has been screened for in vitro anti-proliferative activity revealing considerable activity. International Union of Crystallography 2023-10-05 /pmc/articles/PMC10626967/ /pubmed/37936857 http://dx.doi.org/10.1107/S2056989023008526 Text en © Mohamed-Ezzat et al. 2023 https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution (CC-BY) Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
spellingShingle Research Communications
Mohamed-Ezzat, Reham A.
Kariuki, Benson M.
Srour, Aladdin M.
Synthesis, crystal structure and in vitro anti-proliferative activity of 2-[(4-acetyl­phen­yl)carbamo­yl]phenyl acetate
title Synthesis, crystal structure and in vitro anti-proliferative activity of 2-[(4-acetyl­phen­yl)carbamo­yl]phenyl acetate
title_full Synthesis, crystal structure and in vitro anti-proliferative activity of 2-[(4-acetyl­phen­yl)carbamo­yl]phenyl acetate
title_fullStr Synthesis, crystal structure and in vitro anti-proliferative activity of 2-[(4-acetyl­phen­yl)carbamo­yl]phenyl acetate
title_full_unstemmed Synthesis, crystal structure and in vitro anti-proliferative activity of 2-[(4-acetyl­phen­yl)carbamo­yl]phenyl acetate
title_short Synthesis, crystal structure and in vitro anti-proliferative activity of 2-[(4-acetyl­phen­yl)carbamo­yl]phenyl acetate
title_sort synthesis, crystal structure and in vitro anti-proliferative activity of 2-[(4-acetyl­phen­yl)carbamo­yl]phenyl acetate
topic Research Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10626967/
https://www.ncbi.nlm.nih.gov/pubmed/37936857
http://dx.doi.org/10.1107/S2056989023008526
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