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Early-life microbiota-immune homeostasis
As the prevalence of allergy and autoimmune disease in industrialized societies continues to rise, improving our understanding of the mechanistic roles behind microbiota-immune homeostasis has become critical for informing therapeutic interventions in cases of dysbiosis. Of particular importance, ar...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10627000/ https://www.ncbi.nlm.nih.gov/pubmed/37936686 http://dx.doi.org/10.3389/fimmu.2023.1266876 |
| _version_ | 1785131448647286784 |
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| author | Reynolds, Hayley M. Bettini, Matthew L. |
| author_facet | Reynolds, Hayley M. Bettini, Matthew L. |
| author_sort | Reynolds, Hayley M. |
| collection | PubMed |
| description | As the prevalence of allergy and autoimmune disease in industrialized societies continues to rise, improving our understanding of the mechanistic roles behind microbiota-immune homeostasis has become critical for informing therapeutic interventions in cases of dysbiosis. Of particular importance, are alterations to intestinal microbiota occurring within the critical neonatal window, during which the immune system is highly vulnerable to environmental exposures. This review will highlight recent literature concerning mechanisms of early-life microbiota-immune homeostasis as well as discuss the potential for therapeutics in restoring dysbiosis in early life. |
| format | Online Article Text |
| id | pubmed-10627000 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2023 |
| publisher | Frontiers Media S.A. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-106270002023-11-07 Early-life microbiota-immune homeostasis Reynolds, Hayley M. Bettini, Matthew L. Front Immunol Immunology As the prevalence of allergy and autoimmune disease in industrialized societies continues to rise, improving our understanding of the mechanistic roles behind microbiota-immune homeostasis has become critical for informing therapeutic interventions in cases of dysbiosis. Of particular importance, are alterations to intestinal microbiota occurring within the critical neonatal window, during which the immune system is highly vulnerable to environmental exposures. This review will highlight recent literature concerning mechanisms of early-life microbiota-immune homeostasis as well as discuss the potential for therapeutics in restoring dysbiosis in early life. Frontiers Media S.A. 2023-10-23 /pmc/articles/PMC10627000/ /pubmed/37936686 http://dx.doi.org/10.3389/fimmu.2023.1266876 Text en Copyright © 2023 Reynolds and Bettini https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| spellingShingle | Immunology Reynolds, Hayley M. Bettini, Matthew L. Early-life microbiota-immune homeostasis |
| title | Early-life microbiota-immune homeostasis |
| title_full | Early-life microbiota-immune homeostasis |
| title_fullStr | Early-life microbiota-immune homeostasis |
| title_full_unstemmed | Early-life microbiota-immune homeostasis |
| title_short | Early-life microbiota-immune homeostasis |
| title_sort | early-life microbiota-immune homeostasis |
| topic | Immunology |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10627000/ https://www.ncbi.nlm.nih.gov/pubmed/37936686 http://dx.doi.org/10.3389/fimmu.2023.1266876 |
| work_keys_str_mv | AT reynoldshayleym earlylifemicrobiotaimmunehomeostasis AT bettinimatthewl earlylifemicrobiotaimmunehomeostasis |