Molecular Mechanisms of Ferroptosis and Their Involvement in Acute Kidney Injury

Ferroptosis is a novel way of regulating cell death, which occurs in a process that is closely linked to intracellular iron metabolism, lipid metabolism, amino acid metabolism, and multiple signaling pathways. The latest research shows that ferroptosis plays a key role in the pathogenesis of acute k...

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Detalles Bibliográficos
Autores principales: Liu, Jie, Han, Xiaoxia, Zhou, Jia, Leng, Yufang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10627075/
https://www.ncbi.nlm.nih.gov/pubmed/37936596
http://dx.doi.org/10.2147/JIR.S427505
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author Liu, Jie
Han, Xiaoxia
Zhou, Jia
Leng, Yufang
author_facet Liu, Jie
Han, Xiaoxia
Zhou, Jia
Leng, Yufang
author_sort Liu, Jie
collection PubMed
description Ferroptosis is a novel way of regulating cell death, which occurs in a process that is closely linked to intracellular iron metabolism, lipid metabolism, amino acid metabolism, and multiple signaling pathways. The latest research shows that ferroptosis plays a key role in the pathogenesis of acute kidney injury (AKI). Ferroptosis may be an important target for treating AKI caused by various reasons, such as ischemia-reperfusion injury, rhabdomyolysis syndrome, sepsis, and nephrotoxic drugs. This paper provides a review on the regulatory mechanisms of ferroptosis and its role in AKI, which may help to provide new research ideas for the treatment of AKI and future research.
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spelling pubmed-106270752023-11-07 Molecular Mechanisms of Ferroptosis and Their Involvement in Acute Kidney Injury Liu, Jie Han, Xiaoxia Zhou, Jia Leng, Yufang J Inflamm Res Review Ferroptosis is a novel way of regulating cell death, which occurs in a process that is closely linked to intracellular iron metabolism, lipid metabolism, amino acid metabolism, and multiple signaling pathways. The latest research shows that ferroptosis plays a key role in the pathogenesis of acute kidney injury (AKI). Ferroptosis may be an important target for treating AKI caused by various reasons, such as ischemia-reperfusion injury, rhabdomyolysis syndrome, sepsis, and nephrotoxic drugs. This paper provides a review on the regulatory mechanisms of ferroptosis and its role in AKI, which may help to provide new research ideas for the treatment of AKI and future research. Dove 2023-11-02 /pmc/articles/PMC10627075/ /pubmed/37936596 http://dx.doi.org/10.2147/JIR.S427505 Text en © 2023 Liu et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Liu, Jie
Han, Xiaoxia
Zhou, Jia
Leng, Yufang
Molecular Mechanisms of Ferroptosis and Their Involvement in Acute Kidney Injury
title Molecular Mechanisms of Ferroptosis and Their Involvement in Acute Kidney Injury
title_full Molecular Mechanisms of Ferroptosis and Their Involvement in Acute Kidney Injury
title_fullStr Molecular Mechanisms of Ferroptosis and Their Involvement in Acute Kidney Injury
title_full_unstemmed Molecular Mechanisms of Ferroptosis and Their Involvement in Acute Kidney Injury
title_short Molecular Mechanisms of Ferroptosis and Their Involvement in Acute Kidney Injury
title_sort molecular mechanisms of ferroptosis and their involvement in acute kidney injury
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10627075/
https://www.ncbi.nlm.nih.gov/pubmed/37936596
http://dx.doi.org/10.2147/JIR.S427505
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