PRMT5 Inhibitors Regulate DNA Damage Repair Pathways in Cancer Cells and Improve Response to PARP Inhibition and Chemotherapies

Expression of protein arginine methyltransferase 5 (PRMT5) is highly positively correlated to DNA damage repair (DDR) and DNA replication pathway genes in many types of cancer cells, including ovarian and breast cancer. In the current study, we investigated whether pharmacologic inhibition of PRMT5...

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Detalles Bibliográficos
Autores principales: Carter, Jack, Hulse, Michael, Sivakumar, Monisha, Burtell, Jessica, Thodima, Venkat, Wang, Min, Agarwal, Anjana, Vykuntam, Komali, Spruance, Jacob, Bhagwat, Neha, Rager, Joseph, Ruggeri, Bruce, Scherle, Peggy, Ito, Koichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10627093/
https://www.ncbi.nlm.nih.gov/pubmed/37861290
http://dx.doi.org/10.1158/2767-9764.CRC-23-0070

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