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Albumin-to-protein ratio in spot urine samples for analysis of proteinuria selectivity in chronic kidney disease
INTRODUCTION: The albumin-to-creatinine ratio and total protein-to-creatinine ratio in spot urine samples have already been validated as surrogates for 24-hour albuminuria and proteinuria measurements. Thus, we hypothesized that the type of proteinuria, detected by the electrophoretic pattern of 24-...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sociedade Brasileira de Nefrologia
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10627120/ https://www.ncbi.nlm.nih.gov/pubmed/36200855 http://dx.doi.org/10.1590/2175-8239-JBN-2022-0079en |
Sumario: | INTRODUCTION: The albumin-to-creatinine ratio and total protein-to-creatinine ratio in spot urine samples have already been validated as surrogates for 24-hour albuminuria and proteinuria measurements. Thus, we hypothesized that the type of proteinuria, detected by the electrophoretic pattern of 24-hour urine, could be predicted by the simple proportion of albumin in the total urine protein content, using the albumin-to-protein ratio (APR). Our study sought to validate the use of APR as a cheaper substitute for urinary protein electrophoresis (UPE). METHODS: Using different mathematical models, we compared, the albumin fraction in 24-hour urine samples by electrophoresis and the APR ratio in spot samples from 42 outpatients with chronic kidney disease (CKD). RESULTS: A strong log-order correlation r = 0.84 (0.75–0.92; 95% CI, p = 0.001) was observed between APR and the albumin fraction in the UPE. CONCLUSION: The APR can substitute electrophoresis in CKD outpatients. |
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