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Material matters: exploring the interplay between natural biomaterials and host immune system

Biomaterials are widely used for various medical purposes, for instance, implants, tissue engineering, medical devices, and drug delivery systems. Natural biomaterials can be obtained from proteins, carbohydrates, and cell-specific sources. However, when these biomaterials are introduced into the bo...

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Autores principales: Tripathi, Alok Shiomurti, Zaki, Magdi E. A., Al-Hussain, Sami A., Dubey, Bidhyut Kumar, Singh, Prabhjot, Rind, Laiba, Yadav, Rajnish Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10627157/
https://www.ncbi.nlm.nih.gov/pubmed/37936689
http://dx.doi.org/10.3389/fimmu.2023.1269960
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author Tripathi, Alok Shiomurti
Zaki, Magdi E. A.
Al-Hussain, Sami A.
Dubey, Bidhyut Kumar
Singh, Prabhjot
Rind, Laiba
Yadav, Rajnish Kumar
author_facet Tripathi, Alok Shiomurti
Zaki, Magdi E. A.
Al-Hussain, Sami A.
Dubey, Bidhyut Kumar
Singh, Prabhjot
Rind, Laiba
Yadav, Rajnish Kumar
author_sort Tripathi, Alok Shiomurti
collection PubMed
description Biomaterials are widely used for various medical purposes, for instance, implants, tissue engineering, medical devices, and drug delivery systems. Natural biomaterials can be obtained from proteins, carbohydrates, and cell-specific sources. However, when these biomaterials are introduced into the body, they trigger an immune response which may lead to rejection and failure of the implanted device or tissue. The immune system recognizes natural biomaterials as foreign substances and triggers the activation of several immune cells, for instance, macrophages, dendritic cells, and T cells. These cells release pro-inflammatory cytokines and chemokines, which recruit other immune cells to the implantation site. The activation of the immune system can lead to an inflammatory response, which can be beneficial or detrimental, depending on the type of natural biomaterial and the extent of the immune response. These biomaterials can also influence the immune response by modulating the behavior of immune cells. For example, biomaterials with specific surface properties, such as charge and hydrophobicity, can affect the activation and differentiation of immune cells. Additionally, biomaterials can be engineered to release immunomodulatory factors, such as anti-inflammatory cytokines, to promote a tolerogenic immune response. In conclusion, the interaction between biomaterials and the body’s immune system is an intricate procedure with potential consequences for the effectiveness of therapeutics and medical devices. A better understanding of this interplay can help to design biomaterials that promote favorable immune responses and minimize adverse reactions.
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spelling pubmed-106271572023-11-07 Material matters: exploring the interplay between natural biomaterials and host immune system Tripathi, Alok Shiomurti Zaki, Magdi E. A. Al-Hussain, Sami A. Dubey, Bidhyut Kumar Singh, Prabhjot Rind, Laiba Yadav, Rajnish Kumar Front Immunol Immunology Biomaterials are widely used for various medical purposes, for instance, implants, tissue engineering, medical devices, and drug delivery systems. Natural biomaterials can be obtained from proteins, carbohydrates, and cell-specific sources. However, when these biomaterials are introduced into the body, they trigger an immune response which may lead to rejection and failure of the implanted device or tissue. The immune system recognizes natural biomaterials as foreign substances and triggers the activation of several immune cells, for instance, macrophages, dendritic cells, and T cells. These cells release pro-inflammatory cytokines and chemokines, which recruit other immune cells to the implantation site. The activation of the immune system can lead to an inflammatory response, which can be beneficial or detrimental, depending on the type of natural biomaterial and the extent of the immune response. These biomaterials can also influence the immune response by modulating the behavior of immune cells. For example, biomaterials with specific surface properties, such as charge and hydrophobicity, can affect the activation and differentiation of immune cells. Additionally, biomaterials can be engineered to release immunomodulatory factors, such as anti-inflammatory cytokines, to promote a tolerogenic immune response. In conclusion, the interaction between biomaterials and the body’s immune system is an intricate procedure with potential consequences for the effectiveness of therapeutics and medical devices. A better understanding of this interplay can help to design biomaterials that promote favorable immune responses and minimize adverse reactions. Frontiers Media S.A. 2023-10-23 /pmc/articles/PMC10627157/ /pubmed/37936689 http://dx.doi.org/10.3389/fimmu.2023.1269960 Text en Copyright © 2023 Tripathi, Zaki, Al-Hussain, Dubey, Singh, Rind and Yadav https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Tripathi, Alok Shiomurti
Zaki, Magdi E. A.
Al-Hussain, Sami A.
Dubey, Bidhyut Kumar
Singh, Prabhjot
Rind, Laiba
Yadav, Rajnish Kumar
Material matters: exploring the interplay between natural biomaterials and host immune system
title Material matters: exploring the interplay between natural biomaterials and host immune system
title_full Material matters: exploring the interplay between natural biomaterials and host immune system
title_fullStr Material matters: exploring the interplay between natural biomaterials and host immune system
title_full_unstemmed Material matters: exploring the interplay between natural biomaterials and host immune system
title_short Material matters: exploring the interplay between natural biomaterials and host immune system
title_sort material matters: exploring the interplay between natural biomaterials and host immune system
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10627157/
https://www.ncbi.nlm.nih.gov/pubmed/37936689
http://dx.doi.org/10.3389/fimmu.2023.1269960
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