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Low BMI, blood calcium and vitamin D, kyphosis time, and outdoor activity time are independent risk factors for osteoporosis in postmenopausal women

AIM: To explore the risk factors of osteoporosis in postmenopausal women in China. METHOD: This study collected all patient data from January 2014 to December 2015. Basic information and questionnaires were collected from 524 postmenopausal women in Sanya and Hainan Province. The questionnaire was a...

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Autores principales: Tang, Guo, Feng, Long, Pei, Yu, Gu, Zhaoyan, Chen, Tingting, Feng, Zeguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10627178/
https://www.ncbi.nlm.nih.gov/pubmed/37937050
http://dx.doi.org/10.3389/fendo.2023.1154927
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author Tang, Guo
Feng, Long
Pei, Yu
Gu, Zhaoyan
Chen, Tingting
Feng, Zeguo
author_facet Tang, Guo
Feng, Long
Pei, Yu
Gu, Zhaoyan
Chen, Tingting
Feng, Zeguo
author_sort Tang, Guo
collection PubMed
description AIM: To explore the risk factors of osteoporosis in postmenopausal women in China. METHOD: This study collected all patient data from January 2014 to December 2015. Basic information and questionnaires were collected from 524 postmenopausal women in Sanya and Hainan Province. The questionnaire was administered to the enrolled participants by endocrinologists. Biochemical parameters were measured using fasting blood samples, and bone density was measured by dual energy X-ray absorptiometry at the department of radiology of Hainan hospital, PLA General Hospital. Participants with an R-value of ≤-2.5 were diagnosed with osteoporosis. After deleting missing values for each factor, 334 participants were divided into the osteoporosis (n=35) and non-osteoporosis (n=299) groups according to the R-values. RESULTS: The participants had a median age of 60.8 years (range: 44–94 years). Among the 334 postmenopausal women included in this study, 35 (10.5%) were diagnosed with osteoporosis. Univariate analysis showed statistically significant differences in age, BMI, type of work, alkaline phosphatase, years of smoking, blood calcium levels, kyphosis, fracture, and asthma between the two groups (P<0.05). In addition, multivariate logistic analysis showed that age (odds ratio [OR]: 1.185, 95% confidence interval [CI]: 1.085–1.293, P<0.001) and kyphosis times (OR:1.468, 95% CI: 1.076–2.001, P=0.015) were positively correlated with postmenopausal osteoporosis, whereas BMI (OR: 0.717, 95% CI: 0.617–0.832, P<0.001), blood calcium levels (OR: 0.920, 95% CI: 0.854-0.991, P=0.027), vitamin D levels (OR: 0.787, 95% CI: 0.674–0.918, P=0.002), and outdoor activity time (OR: 0.556, 95% CI: 0.338-0.915, P=0.021) were negatively correlated with postmenopausal osteoporosis. CONCLUSION: Low BMI, blood calcium and vitamin D levels, kyphosis time, and outdoor activity time are independent risk factors for osteoporosis in postmenopausal women.
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spelling pubmed-106271782023-11-07 Low BMI, blood calcium and vitamin D, kyphosis time, and outdoor activity time are independent risk factors for osteoporosis in postmenopausal women Tang, Guo Feng, Long Pei, Yu Gu, Zhaoyan Chen, Tingting Feng, Zeguo Front Endocrinol (Lausanne) Endocrinology AIM: To explore the risk factors of osteoporosis in postmenopausal women in China. METHOD: This study collected all patient data from January 2014 to December 2015. Basic information and questionnaires were collected from 524 postmenopausal women in Sanya and Hainan Province. The questionnaire was administered to the enrolled participants by endocrinologists. Biochemical parameters were measured using fasting blood samples, and bone density was measured by dual energy X-ray absorptiometry at the department of radiology of Hainan hospital, PLA General Hospital. Participants with an R-value of ≤-2.5 were diagnosed with osteoporosis. After deleting missing values for each factor, 334 participants were divided into the osteoporosis (n=35) and non-osteoporosis (n=299) groups according to the R-values. RESULTS: The participants had a median age of 60.8 years (range: 44–94 years). Among the 334 postmenopausal women included in this study, 35 (10.5%) were diagnosed with osteoporosis. Univariate analysis showed statistically significant differences in age, BMI, type of work, alkaline phosphatase, years of smoking, blood calcium levels, kyphosis, fracture, and asthma between the two groups (P<0.05). In addition, multivariate logistic analysis showed that age (odds ratio [OR]: 1.185, 95% confidence interval [CI]: 1.085–1.293, P<0.001) and kyphosis times (OR:1.468, 95% CI: 1.076–2.001, P=0.015) were positively correlated with postmenopausal osteoporosis, whereas BMI (OR: 0.717, 95% CI: 0.617–0.832, P<0.001), blood calcium levels (OR: 0.920, 95% CI: 0.854-0.991, P=0.027), vitamin D levels (OR: 0.787, 95% CI: 0.674–0.918, P=0.002), and outdoor activity time (OR: 0.556, 95% CI: 0.338-0.915, P=0.021) were negatively correlated with postmenopausal osteoporosis. CONCLUSION: Low BMI, blood calcium and vitamin D levels, kyphosis time, and outdoor activity time are independent risk factors for osteoporosis in postmenopausal women. Frontiers Media S.A. 2023-10-23 /pmc/articles/PMC10627178/ /pubmed/37937050 http://dx.doi.org/10.3389/fendo.2023.1154927 Text en Copyright © 2023 Tang, Feng, Pei, Gu, Chen and Feng https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Tang, Guo
Feng, Long
Pei, Yu
Gu, Zhaoyan
Chen, Tingting
Feng, Zeguo
Low BMI, blood calcium and vitamin D, kyphosis time, and outdoor activity time are independent risk factors for osteoporosis in postmenopausal women
title Low BMI, blood calcium and vitamin D, kyphosis time, and outdoor activity time are independent risk factors for osteoporosis in postmenopausal women
title_full Low BMI, blood calcium and vitamin D, kyphosis time, and outdoor activity time are independent risk factors for osteoporosis in postmenopausal women
title_fullStr Low BMI, blood calcium and vitamin D, kyphosis time, and outdoor activity time are independent risk factors for osteoporosis in postmenopausal women
title_full_unstemmed Low BMI, blood calcium and vitamin D, kyphosis time, and outdoor activity time are independent risk factors for osteoporosis in postmenopausal women
title_short Low BMI, blood calcium and vitamin D, kyphosis time, and outdoor activity time are independent risk factors for osteoporosis in postmenopausal women
title_sort low bmi, blood calcium and vitamin d, kyphosis time, and outdoor activity time are independent risk factors for osteoporosis in postmenopausal women
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10627178/
https://www.ncbi.nlm.nih.gov/pubmed/37937050
http://dx.doi.org/10.3389/fendo.2023.1154927
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