Differential gradients of immunotherapy vs targeted therapy efficacy according to the sun-exposure pattern of the site of occurrence of primary melanoma: a multicenter prospective cohort study (MelBase)

BACKGROUND: The tumor mutational burden (TMB) is high in melanomas owing to UV-induced oncogenesis. While a high TMB is a predictive biomarker of response to PD-1 inhibitors, it may be associated with the rise of resistant clones to targeted therapy over time. We hypothesized that survivals may depe...

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Detalles Bibliográficos
Autores principales: Russo, David, Dalle, Stéphane, Dereure, Olivier, Mortier, Laurent, Dalac-Rat, Sophie, Dutriaux, Caroline, Leccia, Marie-Thérèse, Legoupil, Delphine, Montaudié, Henri, Maubec, Eve, De Quatrebarbes, Julie, Arnault, Jean-Philippe, Brocard, Florence Granel, Saïag, Philippe, Dreno, Brigitte, Allayous, Clara, Oriano, Bastien, Lefevre, Wendy, Lebbé, Céleste, Boussemart, Lise
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10627180/
https://www.ncbi.nlm.nih.gov/pubmed/37936607
http://dx.doi.org/10.3389/fonc.2023.1250026

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