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Five families of diverse DNA viruses comprehensively restructure the nucleus

Many viruses have evolved ways to restructure their host cell’s nucleus profoundly and unexpectedly upon infection. In particular, DNA viruses that need to commandeer their host’s cellular synthetic functions to produce their progeny can induce the condensation and margination of host chromatin duri...

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Detalles Bibliográficos
Autores principales: Rosemarie, Quincy, Sugden, Bill
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10627436/
https://www.ncbi.nlm.nih.gov/pubmed/37930945
http://dx.doi.org/10.1371/journal.pbio.3002347
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author Rosemarie, Quincy
Sugden, Bill
author_facet Rosemarie, Quincy
Sugden, Bill
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description Many viruses have evolved ways to restructure their host cell’s nucleus profoundly and unexpectedly upon infection. In particular, DNA viruses that need to commandeer their host’s cellular synthetic functions to produce their progeny can induce the condensation and margination of host chromatin during productive infection, a phenomenon known as virus-induced reorganization of cellular chromatin (ROCC). These ROCC-inducing DNA viruses belong to 5 families (herpesviruses, baculoviruses, adenoviruses, parvoviruses, and geminiviruses) that infect a wide range of hosts and are important for human and ecosystem health, as well as for biotechnology. Although the study of virus-induced ROCC is in its infancy, investigations are already raising important questions, such as why only some DNA viruses that replicate their genomes in the nucleus elicit ROCC. Studying the shared and distinct properties of ROCC-inducing viruses will provide valuable insights into viral reorganization of host chromatin that could have implications for future therapies that target the viral life cycle.
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spelling pubmed-106274362023-11-07 Five families of diverse DNA viruses comprehensively restructure the nucleus Rosemarie, Quincy Sugden, Bill PLoS Biol Essay Many viruses have evolved ways to restructure their host cell’s nucleus profoundly and unexpectedly upon infection. In particular, DNA viruses that need to commandeer their host’s cellular synthetic functions to produce their progeny can induce the condensation and margination of host chromatin during productive infection, a phenomenon known as virus-induced reorganization of cellular chromatin (ROCC). These ROCC-inducing DNA viruses belong to 5 families (herpesviruses, baculoviruses, adenoviruses, parvoviruses, and geminiviruses) that infect a wide range of hosts and are important for human and ecosystem health, as well as for biotechnology. Although the study of virus-induced ROCC is in its infancy, investigations are already raising important questions, such as why only some DNA viruses that replicate their genomes in the nucleus elicit ROCC. Studying the shared and distinct properties of ROCC-inducing viruses will provide valuable insights into viral reorganization of host chromatin that could have implications for future therapies that target the viral life cycle. Public Library of Science 2023-11-06 /pmc/articles/PMC10627436/ /pubmed/37930945 http://dx.doi.org/10.1371/journal.pbio.3002347 Text en © 2023 Rosemarie, Sugden https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Essay
Rosemarie, Quincy
Sugden, Bill
Five families of diverse DNA viruses comprehensively restructure the nucleus
title Five families of diverse DNA viruses comprehensively restructure the nucleus
title_full Five families of diverse DNA viruses comprehensively restructure the nucleus
title_fullStr Five families of diverse DNA viruses comprehensively restructure the nucleus
title_full_unstemmed Five families of diverse DNA viruses comprehensively restructure the nucleus
title_short Five families of diverse DNA viruses comprehensively restructure the nucleus
title_sort five families of diverse dna viruses comprehensively restructure the nucleus
topic Essay
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10627436/
https://www.ncbi.nlm.nih.gov/pubmed/37930945
http://dx.doi.org/10.1371/journal.pbio.3002347
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