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Theoretical analysis reveals a role for RAF conformational autoinhibition in paradoxical activation
RAF kinase inhibitors can, under certain conditions, increase RAF kinase signaling. This process, which is commonly referred to as ‘paradoxical activation’ (PA), is incompletely understood. We use mathematical and computational modeling to investigate PA and derive rigorous analytical expressions th...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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eLife Sciences Publications, Ltd
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10627510/ https://www.ncbi.nlm.nih.gov/pubmed/37823369 http://dx.doi.org/10.7554/eLife.82739 |