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Structural basis for kinase inhibition in the tripartite E. coli HipBST toxin–antitoxin system

Many bacteria encode multiple toxin–antitoxin (TA) systems targeting separate, but closely related, cellular functions. The toxin of the Escherichia coli hipBA system, HipA, is a kinase that inhibits translation via phosphorylation of glutamyl-tRNA synthetase. Enteropathogenic E. coli O127:H6 encode...

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Detalles Bibliográficos
Autores principales:	Bærentsen, René L, Nielsen, Stine V, Skjerning, Ragnhild B, Lyngsø, Jeppe, Bisiak, Francesco, Pedersen, Jan Skov, Gerdes, Kenn, Sørensen, Michael A, Brodersen, Ditlev E
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2023
Materias:	Microbiology and Infectious Disease
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10627512/ https://www.ncbi.nlm.nih.gov/pubmed/37929938 http://dx.doi.org/10.7554/eLife.90400

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