Beyond the Checkpoint: Severe Axitinib-induced Liver Injury

Understanding the potential adverse effects associated with oncological treatments is crucial in the clinical care of patients with cancer. We describe the first case report delineating severe acute liver injury secondary to axitinib. This is a case of metastatic renal cell carcinoma treated with ax...

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Autores principales: Yeo, Yee Hui, Ayoub, Walid, Yang, Ju Dong, Kuo, Alexander, Trivedi, Hirsh D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10627582/
https://www.ncbi.nlm.nih.gov/pubmed/37937065
http://dx.doi.org/10.14309/crj.0000000000001177
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author Yeo, Yee Hui
Ayoub, Walid
Yang, Ju Dong
Kuo, Alexander
Trivedi, Hirsh D.
author_facet Yeo, Yee Hui
Ayoub, Walid
Yang, Ju Dong
Kuo, Alexander
Trivedi, Hirsh D.
author_sort Yeo, Yee Hui
collection PubMed
description Understanding the potential adverse effects associated with oncological treatments is crucial in the clinical care of patients with cancer. We describe the first case report delineating severe acute liver injury secondary to axitinib. This is a case of metastatic renal cell carcinoma treated with axitinib and pembrolizumab, complicated by a severe axitinib-induced liver injury, characterized by significant elevations of hepatocellular and cholestatic liver enzymes during initial treatment and rechallenge of axitinib. Remarkably, the liver chemistries normalized upon discontinuation of the medication.
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spelling pubmed-106275822023-11-07 Beyond the Checkpoint: Severe Axitinib-induced Liver Injury Yeo, Yee Hui Ayoub, Walid Yang, Ju Dong Kuo, Alexander Trivedi, Hirsh D. ACG Case Rep J Case Report Understanding the potential adverse effects associated with oncological treatments is crucial in the clinical care of patients with cancer. We describe the first case report delineating severe acute liver injury secondary to axitinib. This is a case of metastatic renal cell carcinoma treated with axitinib and pembrolizumab, complicated by a severe axitinib-induced liver injury, characterized by significant elevations of hepatocellular and cholestatic liver enzymes during initial treatment and rechallenge of axitinib. Remarkably, the liver chemistries normalized upon discontinuation of the medication. Wolters Kluwer 2023-11-04 /pmc/articles/PMC10627582/ /pubmed/37937065 http://dx.doi.org/10.14309/crj.0000000000001177 Text en © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Yeo, Yee Hui
Ayoub, Walid
Yang, Ju Dong
Kuo, Alexander
Trivedi, Hirsh D.
Beyond the Checkpoint: Severe Axitinib-induced Liver Injury
title Beyond the Checkpoint: Severe Axitinib-induced Liver Injury
title_full Beyond the Checkpoint: Severe Axitinib-induced Liver Injury
title_fullStr Beyond the Checkpoint: Severe Axitinib-induced Liver Injury
title_full_unstemmed Beyond the Checkpoint: Severe Axitinib-induced Liver Injury
title_short Beyond the Checkpoint: Severe Axitinib-induced Liver Injury
title_sort beyond the checkpoint: severe axitinib-induced liver injury
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10627582/
https://www.ncbi.nlm.nih.gov/pubmed/37937065
http://dx.doi.org/10.14309/crj.0000000000001177
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