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Risk factors for distant metastasis of Chondrosarcoma in the middle-aged and elderly people

Chondrosarcoma is the second most common primary bone malignancy with the highest incidence in middle-aged and elderly people, where distant metastasis (DM) still leads to poor prognosis. The purpose of this study was to construct a nomogram for studying the diagnosis of DM in middle-aged and elderl...

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Autor principal: Deng, Guang-hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10627602/
https://www.ncbi.nlm.nih.gov/pubmed/37932996
http://dx.doi.org/10.1097/MD.0000000000035562
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author Deng, Guang-hua
author_facet Deng, Guang-hua
author_sort Deng, Guang-hua
collection PubMed
description Chondrosarcoma is the second most common primary bone malignancy with the highest incidence in middle-aged and elderly people, where distant metastasis (DM) still leads to poor prognosis. The purpose of this study was to construct a nomogram for studying the diagnosis of DM in middle-aged and elderly patients with chondrosarcoma. Data on chondrosarcoma patients aged ≥ 40 years diagnosed from 2004 to 2015 were extracted from the Surveillance, Epidemiology, and End Results (SEER) database. The data were divided into a training set and an internal validation set according to a 7:3 ratio, and the training set data were screened for independent risk factors for DM in chondrosarcoma patients using univariate and multivariate logistic regression analysis. The screened independent risk factors were then used to build a nomogram. In addition, data from 144 patients with chondrosarcoma aged ≥ 40 years diagnosed in a tertiary hospital in China from 2012 to 2021 were collected as the external validation set. The results were evaluated by receiver operating characteristic curves, calibration curves, and decision curve analysis in the training set, internal validation set, and external validation set. A total of 1462 middle-aged and elderly patients with chondrosarcoma were included, and 92 (6.29%) had DM at the time of diagnosis. Independent risk factors for DM in middle-aged and elderly patients with chondrosarcoma included being married (OR: 2.119, 95% CI: 1.094–4.105), histological type of dedifferentiated chondrosarcoma (OR: 1.290, 95% CI: 1.110–1.499), high-grade tumor (OR: 1.511, 95% CI: 1.079–2.115), T3 stage (OR: 4.184, 95% CI: 1.977– 8.858), and N1 staging (OR: 5.666, 95% CI: 1.964–16.342). The area under the receiver operating characteristic curve (AUC) was 0.857, 0.820, and 0.859 in the training set, internal validation set, and external validation set, respectively. The results of the calibration curve and decision curve analysis also confirmed that the established nomogram could accurately predict DM in middle-aged and elderly patients with chondrosarcoma. Married, histological type of dedifferentiated chondrosarcoma, high-grade tumor, T3 stage, and N1 stage are independent risk factors for DM in middle-aged and elderly chondrosarcoma patients, and clinicians should see more attention.
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spelling pubmed-106276022023-11-07 Risk factors for distant metastasis of Chondrosarcoma in the middle-aged and elderly people Deng, Guang-hua Medicine (Baltimore) 7100 Chondrosarcoma is the second most common primary bone malignancy with the highest incidence in middle-aged and elderly people, where distant metastasis (DM) still leads to poor prognosis. The purpose of this study was to construct a nomogram for studying the diagnosis of DM in middle-aged and elderly patients with chondrosarcoma. Data on chondrosarcoma patients aged ≥ 40 years diagnosed from 2004 to 2015 were extracted from the Surveillance, Epidemiology, and End Results (SEER) database. The data were divided into a training set and an internal validation set according to a 7:3 ratio, and the training set data were screened for independent risk factors for DM in chondrosarcoma patients using univariate and multivariate logistic regression analysis. The screened independent risk factors were then used to build a nomogram. In addition, data from 144 patients with chondrosarcoma aged ≥ 40 years diagnosed in a tertiary hospital in China from 2012 to 2021 were collected as the external validation set. The results were evaluated by receiver operating characteristic curves, calibration curves, and decision curve analysis in the training set, internal validation set, and external validation set. A total of 1462 middle-aged and elderly patients with chondrosarcoma were included, and 92 (6.29%) had DM at the time of diagnosis. Independent risk factors for DM in middle-aged and elderly patients with chondrosarcoma included being married (OR: 2.119, 95% CI: 1.094–4.105), histological type of dedifferentiated chondrosarcoma (OR: 1.290, 95% CI: 1.110–1.499), high-grade tumor (OR: 1.511, 95% CI: 1.079–2.115), T3 stage (OR: 4.184, 95% CI: 1.977– 8.858), and N1 staging (OR: 5.666, 95% CI: 1.964–16.342). The area under the receiver operating characteristic curve (AUC) was 0.857, 0.820, and 0.859 in the training set, internal validation set, and external validation set, respectively. The results of the calibration curve and decision curve analysis also confirmed that the established nomogram could accurately predict DM in middle-aged and elderly patients with chondrosarcoma. Married, histological type of dedifferentiated chondrosarcoma, high-grade tumor, T3 stage, and N1 stage are independent risk factors for DM in middle-aged and elderly chondrosarcoma patients, and clinicians should see more attention. Lippincott Williams & Wilkins 2023-11-03 /pmc/articles/PMC10627602/ /pubmed/37932996 http://dx.doi.org/10.1097/MD.0000000000035562 Text en Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle 7100
Deng, Guang-hua
Risk factors for distant metastasis of Chondrosarcoma in the middle-aged and elderly people
title Risk factors for distant metastasis of Chondrosarcoma in the middle-aged and elderly people
title_full Risk factors for distant metastasis of Chondrosarcoma in the middle-aged and elderly people
title_fullStr Risk factors for distant metastasis of Chondrosarcoma in the middle-aged and elderly people
title_full_unstemmed Risk factors for distant metastasis of Chondrosarcoma in the middle-aged and elderly people
title_short Risk factors for distant metastasis of Chondrosarcoma in the middle-aged and elderly people
title_sort risk factors for distant metastasis of chondrosarcoma in the middle-aged and elderly people
topic 7100
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10627602/
https://www.ncbi.nlm.nih.gov/pubmed/37932996
http://dx.doi.org/10.1097/MD.0000000000035562
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