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Feasibility of (125)I brachytherapy combined with arterial infusion chemotherapy in patients with advanced pancreatic cancer
To evaluation the feasibility of Iodine-125 (¹²(5)I) brachytherapy combined with arterial infusion chemotherapy in patients with advanced pancreatic cancer. A total of 72 cases with Stage III and IV were retrospectively reviewed. 23 cases receiving (125)I brachytherapy were classified as Group A. 27...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10627645/ https://www.ncbi.nlm.nih.gov/pubmed/37933058 http://dx.doi.org/10.1097/MD.0000000000035033 |
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author | Huang, Shujing Cao, Yanqing Wang, Rui Liu, Huimin Wang, Ting Yang, Shu |
author_facet | Huang, Shujing Cao, Yanqing Wang, Rui Liu, Huimin Wang, Ting Yang, Shu |
author_sort | Huang, Shujing |
collection | PubMed |
description | To evaluation the feasibility of Iodine-125 (¹²(5)I) brachytherapy combined with arterial infusion chemotherapy in patients with advanced pancreatic cancer. A total of 72 cases with Stage III and IV were retrospectively reviewed. 23 cases receiving (125)I brachytherapy were classified as Group A. 27 cases receiving arterial infusion chemotherapy (gemcitabine + cisplatin, GP) were classified as Group B and 22 cases receiving (125)I brachytherapy combined with arterial infusion chemotherapy (GP) were classified as Group C. The evaluated indications were local control rate, survival rate, carbohydrate antigen 19-9, pain relief, and Karnofsky physical scores. Analysis of Variancep, Pearson chi-square test and Kaplan–Meier curves were used for analysis. The local control rate of group A and group C was significantly higher than group B (P < .001). Pearson chi-square test showed statistical difference of the 3 groups (χ(2) = 12.969, P = .044). The median survival of group A,B and C was 9 months, 6 months and 13 months, respectively. The survival time of group C was significantly higher than group B (χ(2) = 5.403, P = .020). The Log rank test showed statistical difference in the survival curve of the 3 groups (χ(2) = 6.501, P = .039). The difference of carbohydrate antigen 19-9 decline percentage between group B and C group was statistically significant (χ(2) = 5.959, P = .015). Patients in group A and group C relieved form pain after treatment with statistically significant (P < .001). Pain relief was much more effective in patients who received (125)I brachytherapy. Karnofsky physical scores after treatment were statistically higher than those before treatment in each group (P < .001). (125)I brachytherapy maybe one of the effective, safe and feasible alternative treatment of advanced pancreatic cancer. ¹²(5)I brachytherapy combined with arterial infusion chemotherapy was effective in the treatment of advanced pancreatic cancer. |
format | Online Article Text |
id | pubmed-10627645 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-106276452023-11-07 Feasibility of (125)I brachytherapy combined with arterial infusion chemotherapy in patients with advanced pancreatic cancer Huang, Shujing Cao, Yanqing Wang, Rui Liu, Huimin Wang, Ting Yang, Shu Medicine (Baltimore) 5700 To evaluation the feasibility of Iodine-125 (¹²(5)I) brachytherapy combined with arterial infusion chemotherapy in patients with advanced pancreatic cancer. A total of 72 cases with Stage III and IV were retrospectively reviewed. 23 cases receiving (125)I brachytherapy were classified as Group A. 27 cases receiving arterial infusion chemotherapy (gemcitabine + cisplatin, GP) were classified as Group B and 22 cases receiving (125)I brachytherapy combined with arterial infusion chemotherapy (GP) were classified as Group C. The evaluated indications were local control rate, survival rate, carbohydrate antigen 19-9, pain relief, and Karnofsky physical scores. Analysis of Variancep, Pearson chi-square test and Kaplan–Meier curves were used for analysis. The local control rate of group A and group C was significantly higher than group B (P < .001). Pearson chi-square test showed statistical difference of the 3 groups (χ(2) = 12.969, P = .044). The median survival of group A,B and C was 9 months, 6 months and 13 months, respectively. The survival time of group C was significantly higher than group B (χ(2) = 5.403, P = .020). The Log rank test showed statistical difference in the survival curve of the 3 groups (χ(2) = 6.501, P = .039). The difference of carbohydrate antigen 19-9 decline percentage between group B and C group was statistically significant (χ(2) = 5.959, P = .015). Patients in group A and group C relieved form pain after treatment with statistically significant (P < .001). Pain relief was much more effective in patients who received (125)I brachytherapy. Karnofsky physical scores after treatment were statistically higher than those before treatment in each group (P < .001). (125)I brachytherapy maybe one of the effective, safe and feasible alternative treatment of advanced pancreatic cancer. ¹²(5)I brachytherapy combined with arterial infusion chemotherapy was effective in the treatment of advanced pancreatic cancer. Lippincott Williams & Wilkins 2023-11-03 /pmc/articles/PMC10627645/ /pubmed/37933058 http://dx.doi.org/10.1097/MD.0000000000035033 Text en Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | 5700 Huang, Shujing Cao, Yanqing Wang, Rui Liu, Huimin Wang, Ting Yang, Shu Feasibility of (125)I brachytherapy combined with arterial infusion chemotherapy in patients with advanced pancreatic cancer |
title | Feasibility of (125)I brachytherapy combined with arterial infusion chemotherapy in patients with advanced pancreatic cancer |
title_full | Feasibility of (125)I brachytherapy combined with arterial infusion chemotherapy in patients with advanced pancreatic cancer |
title_fullStr | Feasibility of (125)I brachytherapy combined with arterial infusion chemotherapy in patients with advanced pancreatic cancer |
title_full_unstemmed | Feasibility of (125)I brachytherapy combined with arterial infusion chemotherapy in patients with advanced pancreatic cancer |
title_short | Feasibility of (125)I brachytherapy combined with arterial infusion chemotherapy in patients with advanced pancreatic cancer |
title_sort | feasibility of (125)i brachytherapy combined with arterial infusion chemotherapy in patients with advanced pancreatic cancer |
topic | 5700 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10627645/ https://www.ncbi.nlm.nih.gov/pubmed/37933058 http://dx.doi.org/10.1097/MD.0000000000035033 |
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