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Causal relationship between ADHD and frozen shoulder: Two-sample Mendelian randomization

To investigate the causal relationship between attention deficit and hyperactivity disorder (ADHD) and frozen shoulder using Mendelian randomization (MR). Data were pooled from large-scale genome wide association studies, and genetic loci that were independent of each other and associated with ADHD...

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Autor principal: Deng, Guang-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10627672/
https://www.ncbi.nlm.nih.gov/pubmed/37933000
http://dx.doi.org/10.1097/MD.0000000000035883
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author Deng, Guang-Hua
author_facet Deng, Guang-Hua
author_sort Deng, Guang-Hua
collection PubMed
description To investigate the causal relationship between attention deficit and hyperactivity disorder (ADHD) and frozen shoulder using Mendelian randomization (MR). Data were pooled from large-scale genome wide association studies, and genetic loci that were independent of each other and associated with ADHD and frozen shoulder in people of European ancestry were selected as instrumental variables. Three MR analyses, inverse variance weighting, weighted median and MR-Egger, were used to investigate the causal relationship between ADHD and frozen shoulder. Heterogeneity and multiplicity tests were used, and sensitivity analyses were performed using the “leave-one-out” method to explore the robustness of the results. The inverse variance weighting results showed an OR (95 % CI) of 1.12 (1.00–1.25), P = .046, indicating a causal relationship between ADHD and frozen shoulder. And no heterogeneity and multiplicity were found by the test and sensitivity analysis also showed robust results. The present study used a two-sample MR analysis, and by analyzing and exploring the genetic data, the study showed that ADHD is a risk factor for developing frozen shoulder, and patients with ADHD are more likely to suffer from frozen shoulder.
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spelling pubmed-106276722023-11-07 Causal relationship between ADHD and frozen shoulder: Two-sample Mendelian randomization Deng, Guang-Hua Medicine (Baltimore) 4700 To investigate the causal relationship between attention deficit and hyperactivity disorder (ADHD) and frozen shoulder using Mendelian randomization (MR). Data were pooled from large-scale genome wide association studies, and genetic loci that were independent of each other and associated with ADHD and frozen shoulder in people of European ancestry were selected as instrumental variables. Three MR analyses, inverse variance weighting, weighted median and MR-Egger, were used to investigate the causal relationship between ADHD and frozen shoulder. Heterogeneity and multiplicity tests were used, and sensitivity analyses were performed using the “leave-one-out” method to explore the robustness of the results. The inverse variance weighting results showed an OR (95 % CI) of 1.12 (1.00–1.25), P = .046, indicating a causal relationship between ADHD and frozen shoulder. And no heterogeneity and multiplicity were found by the test and sensitivity analysis also showed robust results. The present study used a two-sample MR analysis, and by analyzing and exploring the genetic data, the study showed that ADHD is a risk factor for developing frozen shoulder, and patients with ADHD are more likely to suffer from frozen shoulder. Lippincott Williams & Wilkins 2023-11-03 /pmc/articles/PMC10627672/ /pubmed/37933000 http://dx.doi.org/10.1097/MD.0000000000035883 Text en Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle 4700
Deng, Guang-Hua
Causal relationship between ADHD and frozen shoulder: Two-sample Mendelian randomization
title Causal relationship between ADHD and frozen shoulder: Two-sample Mendelian randomization
title_full Causal relationship between ADHD and frozen shoulder: Two-sample Mendelian randomization
title_fullStr Causal relationship between ADHD and frozen shoulder: Two-sample Mendelian randomization
title_full_unstemmed Causal relationship between ADHD and frozen shoulder: Two-sample Mendelian randomization
title_short Causal relationship between ADHD and frozen shoulder: Two-sample Mendelian randomization
title_sort causal relationship between adhd and frozen shoulder: two-sample mendelian randomization
topic 4700
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10627672/
https://www.ncbi.nlm.nih.gov/pubmed/37933000
http://dx.doi.org/10.1097/MD.0000000000035883
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