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Effectiveness of alpha-lipoic acid in patients with neuropathic pain associated with type I and type II diabetes mellitus: A systematic review and meta-analysis

BACKGROUND: This systematic review explores the most current evidence regarding the mechanisms of neuropathic pain in patients with different types of diabetes and how this pain affects different functional and structural components of the neuroanatomical pain pathways. The review also seeks to prov...

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Autores principales: Orellana-Donoso, Mathias, López-Chaparro, Michelle, Barahona-Vásquez, Marisol, Santana-Machuca, Andrés, Bruna-Mejias, Alejandro, Nova-Baeza, Pablo, Valenzuela-Fuenzalida, Juan José
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10627688/
https://www.ncbi.nlm.nih.gov/pubmed/37933068
http://dx.doi.org/10.1097/MD.0000000000035368
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author Orellana-Donoso, Mathias
López-Chaparro, Michelle
Barahona-Vásquez, Marisol
Santana-Machuca, Andrés
Bruna-Mejias, Alejandro
Nova-Baeza, Pablo
Valenzuela-Fuenzalida, Juan José
author_facet Orellana-Donoso, Mathias
López-Chaparro, Michelle
Barahona-Vásquez, Marisol
Santana-Machuca, Andrés
Bruna-Mejias, Alejandro
Nova-Baeza, Pablo
Valenzuela-Fuenzalida, Juan José
author_sort Orellana-Donoso, Mathias
collection PubMed
description BACKGROUND: This systematic review explores the most current evidence regarding the mechanisms of neuropathic pain in patients with different types of diabetes and how this pain affects different functional and structural components of the neuroanatomical pain pathways. The review also seeks to provide guidelines for the best approach and treatment for patients experiencing this type of pain. The objective is to determine the effectiveness of alpha-lipoic acid (ALA) in improving functional and symptomatic outcomes in patients with diabetes mellitus type I and type II. OBJECTIVE: To determine the effectiveness of alpha-lipoic acid (ALA) in improving functional and symptomatic outcomes in patients with diabetes mellitus type I and type II. METHODS: We systematically search MEDLINE (via PubMed), EMBASE, SCOPUS, the Cochrane Central Register of Controlled Trials, the Cumulative Index to Nursing and Allied Health Literature, and Web of Science databases. RESULTS: The findings of this review show that different forms of ALA do not present statistically significant changes for any of the scales included, including total symptom score (standardized mean difference [SMD] = −3.59, confidence interval [CI] = −4.16 to −3.02, and P < .00001), neuropathy impairment score (SMD = −1.42, CI = −3.68 to 0.84, and P = .22), and neuropathy symptom checklist (SMD = −0.09, CI = −0.15 to −0.02, and P = .01). CONCLUSION: In comparison to the use of a placebo, the findings suggest that ALA does not exhibit significant differences in terms of pain reduction and different functional scales. Moreover, no specific dosages are identified to support the use of ALA for the reduction of neuropathic pain.
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spelling pubmed-106276882023-11-07 Effectiveness of alpha-lipoic acid in patients with neuropathic pain associated with type I and type II diabetes mellitus: A systematic review and meta-analysis Orellana-Donoso, Mathias López-Chaparro, Michelle Barahona-Vásquez, Marisol Santana-Machuca, Andrés Bruna-Mejias, Alejandro Nova-Baeza, Pablo Valenzuela-Fuenzalida, Juan José Medicine (Baltimore) 3200 BACKGROUND: This systematic review explores the most current evidence regarding the mechanisms of neuropathic pain in patients with different types of diabetes and how this pain affects different functional and structural components of the neuroanatomical pain pathways. The review also seeks to provide guidelines for the best approach and treatment for patients experiencing this type of pain. The objective is to determine the effectiveness of alpha-lipoic acid (ALA) in improving functional and symptomatic outcomes in patients with diabetes mellitus type I and type II. OBJECTIVE: To determine the effectiveness of alpha-lipoic acid (ALA) in improving functional and symptomatic outcomes in patients with diabetes mellitus type I and type II. METHODS: We systematically search MEDLINE (via PubMed), EMBASE, SCOPUS, the Cochrane Central Register of Controlled Trials, the Cumulative Index to Nursing and Allied Health Literature, and Web of Science databases. RESULTS: The findings of this review show that different forms of ALA do not present statistically significant changes for any of the scales included, including total symptom score (standardized mean difference [SMD] = −3.59, confidence interval [CI] = −4.16 to −3.02, and P < .00001), neuropathy impairment score (SMD = −1.42, CI = −3.68 to 0.84, and P = .22), and neuropathy symptom checklist (SMD = −0.09, CI = −0.15 to −0.02, and P = .01). CONCLUSION: In comparison to the use of a placebo, the findings suggest that ALA does not exhibit significant differences in terms of pain reduction and different functional scales. Moreover, no specific dosages are identified to support the use of ALA for the reduction of neuropathic pain. Lippincott Williams & Wilkins 2023-11-03 /pmc/articles/PMC10627688/ /pubmed/37933068 http://dx.doi.org/10.1097/MD.0000000000035368 Text en Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle 3200
Orellana-Donoso, Mathias
López-Chaparro, Michelle
Barahona-Vásquez, Marisol
Santana-Machuca, Andrés
Bruna-Mejias, Alejandro
Nova-Baeza, Pablo
Valenzuela-Fuenzalida, Juan José
Effectiveness of alpha-lipoic acid in patients with neuropathic pain associated with type I and type II diabetes mellitus: A systematic review and meta-analysis
title Effectiveness of alpha-lipoic acid in patients with neuropathic pain associated with type I and type II diabetes mellitus: A systematic review and meta-analysis
title_full Effectiveness of alpha-lipoic acid in patients with neuropathic pain associated with type I and type II diabetes mellitus: A systematic review and meta-analysis
title_fullStr Effectiveness of alpha-lipoic acid in patients with neuropathic pain associated with type I and type II diabetes mellitus: A systematic review and meta-analysis
title_full_unstemmed Effectiveness of alpha-lipoic acid in patients with neuropathic pain associated with type I and type II diabetes mellitus: A systematic review and meta-analysis
title_short Effectiveness of alpha-lipoic acid in patients with neuropathic pain associated with type I and type II diabetes mellitus: A systematic review and meta-analysis
title_sort effectiveness of alpha-lipoic acid in patients with neuropathic pain associated with type i and type ii diabetes mellitus: a systematic review and meta-analysis
topic 3200
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10627688/
https://www.ncbi.nlm.nih.gov/pubmed/37933068
http://dx.doi.org/10.1097/MD.0000000000035368
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