The laminin–keratin link shields the nucleus from mechanical deformation and signalling

The mechanical properties of the extracellular matrix dictate tissue behaviour. In epithelial tissues, laminin is a very abundant extracellular matrix component and a key supporting element. Here we show that laminin hinders the mechanoresponses of breast epithelial cells by shielding the nucleus fr...

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Detalles Bibliográficos
Autores principales: Kechagia, Zanetta, Sáez, Pablo, Gómez-González, Manuel, Canales, Brenda, Viswanadha, Srivatsava, Zamarbide, Martín, Andreu, Ion, Koorman, Thijs, Beedle, Amy E. M., Elosegui-Artola, Alberto, Derksen, Patrick W. B., Trepat, Xavier, Arroyo, Marino, Roca-Cusachs, Pere
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10627833/
https://www.ncbi.nlm.nih.gov/pubmed/37709930
http://dx.doi.org/10.1038/s41563-023-01657-3

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