Heterozygote advantage at HLA class I and II loci and reduced risk of colorectal cancer

OBJECTIVE: Reduced diversity at Human Leukocyte Antigen (HLA) loci may adversely affect the host’s ability to recognize tumor neoantigens and subsequently increase disease burden. We hypothesized that increased heterozygosity at HLA loci is associated with a reduced risk of developing colorectal can...

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Detalles Bibliográficos
Autores principales: Tsai, Ya-Yu, Qu, Chenxu, Bonner, Joseph D., Sanz-Pamplona, Rebeca, Lindsey, Sidney S., Melas, Marilena, McDonnell, Kevin J., Idos, Gregory E., Walker, Christopher P., Tsang, Kevin K., Da Silva, Diane M., Moratalla-Navarro, Ferran, Maoz, Asaf, Rennert, Hedy S., Kast, W. Martin, Greenson, Joel K., Moreno, Victor, Rennert, Gad, Gruber, Stephen B., Schmit, Stephanie L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10627840/
https://www.ncbi.nlm.nih.gov/pubmed/37942321
http://dx.doi.org/10.3389/fimmu.2023.1268117

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