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Spatial frequency channels depend on stimulus bandwidth in normal and amblyopic vision: an exploratory factor analysis

The Contrast Sensitivity Function (CSF) is the measure of an observer’s contrast sensitivity as a function of spatial frequency. It is a sensitive measure to assess visual function in fundamental and clinical settings. Human contrast sensitivity is subserved by different spatial frequency channels....

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Autores principales: Reynaud, Alexandre, Min, Seung Hyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10627878/
https://www.ncbi.nlm.nih.gov/pubmed/37941764
http://dx.doi.org/10.3389/fncom.2023.1241455
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author Reynaud, Alexandre
Min, Seung Hyun
author_facet Reynaud, Alexandre
Min, Seung Hyun
author_sort Reynaud, Alexandre
collection PubMed
description The Contrast Sensitivity Function (CSF) is the measure of an observer’s contrast sensitivity as a function of spatial frequency. It is a sensitive measure to assess visual function in fundamental and clinical settings. Human contrast sensitivity is subserved by different spatial frequency channels. Also, it is known that amblyopes have deficits in contrast sensitivity, particularly at high spatial frequencies. Therefore, the aim of this study was to assess whether the contrast sensitivity function is subtended by the same spatial frequency channels in control and amblyopic populations. To determine these spatial frequency channels, we performed an exploratory factor analysis on five datasets of contrasts sensitivity functions of amblyopic and control participants measured using either gratings or noise patches, taken from our previous studies. In the range of 0.25–10 c/d, we identified two spatial frequency channels. When the CSF was measured with noise patches, the spatial frequency channels presented very similar tuning in the amblyopic eye and the fellow eye and were also similar to what was observed in controls. The only major difference was that the weight attributed to the high frequency channel was reduced by approximately 50% in the amblyopic eye. However, when the CSF was measured using gratings, the spatial frequency channels of the amblyopic eye were tuned toward lower spatial frequencies. These findings suggest that there is no mechanistic deficit for contrast sensitivity in amblyopia and that amblyopic vision may just be subjected to excessive internal noise and attenuation at higher spatial frequencies, thereby supporting the use of therapeutic strategies that involve rebalancing contrast.
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spelling pubmed-106278782023-11-08 Spatial frequency channels depend on stimulus bandwidth in normal and amblyopic vision: an exploratory factor analysis Reynaud, Alexandre Min, Seung Hyun Front Comput Neurosci Neuroscience The Contrast Sensitivity Function (CSF) is the measure of an observer’s contrast sensitivity as a function of spatial frequency. It is a sensitive measure to assess visual function in fundamental and clinical settings. Human contrast sensitivity is subserved by different spatial frequency channels. Also, it is known that amblyopes have deficits in contrast sensitivity, particularly at high spatial frequencies. Therefore, the aim of this study was to assess whether the contrast sensitivity function is subtended by the same spatial frequency channels in control and amblyopic populations. To determine these spatial frequency channels, we performed an exploratory factor analysis on five datasets of contrasts sensitivity functions of amblyopic and control participants measured using either gratings or noise patches, taken from our previous studies. In the range of 0.25–10 c/d, we identified two spatial frequency channels. When the CSF was measured with noise patches, the spatial frequency channels presented very similar tuning in the amblyopic eye and the fellow eye and were also similar to what was observed in controls. The only major difference was that the weight attributed to the high frequency channel was reduced by approximately 50% in the amblyopic eye. However, when the CSF was measured using gratings, the spatial frequency channels of the amblyopic eye were tuned toward lower spatial frequencies. These findings suggest that there is no mechanistic deficit for contrast sensitivity in amblyopia and that amblyopic vision may just be subjected to excessive internal noise and attenuation at higher spatial frequencies, thereby supporting the use of therapeutic strategies that involve rebalancing contrast. Frontiers Media S.A. 2023-10-24 /pmc/articles/PMC10627878/ /pubmed/37941764 http://dx.doi.org/10.3389/fncom.2023.1241455 Text en Copyright © 2023 Reynaud and Min. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Reynaud, Alexandre
Min, Seung Hyun
Spatial frequency channels depend on stimulus bandwidth in normal and amblyopic vision: an exploratory factor analysis
title Spatial frequency channels depend on stimulus bandwidth in normal and amblyopic vision: an exploratory factor analysis
title_full Spatial frequency channels depend on stimulus bandwidth in normal and amblyopic vision: an exploratory factor analysis
title_fullStr Spatial frequency channels depend on stimulus bandwidth in normal and amblyopic vision: an exploratory factor analysis
title_full_unstemmed Spatial frequency channels depend on stimulus bandwidth in normal and amblyopic vision: an exploratory factor analysis
title_short Spatial frequency channels depend on stimulus bandwidth in normal and amblyopic vision: an exploratory factor analysis
title_sort spatial frequency channels depend on stimulus bandwidth in normal and amblyopic vision: an exploratory factor analysis
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10627878/
https://www.ncbi.nlm.nih.gov/pubmed/37941764
http://dx.doi.org/10.3389/fncom.2023.1241455
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AT minseunghyun spatialfrequencychannelsdependonstimulusbandwidthinnormalandamblyopicvisionanexploratoryfactoranalysis