Transformation of pancreatic nonfunctioning neuroendocrine tumor into metastatic insulinoma: A rare case report

Pancreatic neuroendocrine tumors can be classified as functional or nonfunctional based on hormone secretion. Management of each entity is different, with nonfunctional tumors being treated with traditional chemotherapy while functional tumors respond well to antihormonal therapy and immunologic age...

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Autores principales: Buddhavarapu, Venkata S., Dhillon, Gagandeep, Grewal, Harpreet Singh, Soles, Brian, Halbur, Luke, Surani, Salim, Kashyap, Rahul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10627923/
https://www.ncbi.nlm.nih.gov/pubmed/37942181
http://dx.doi.org/10.1002/ccr3.8152
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author Buddhavarapu, Venkata S.
Dhillon, Gagandeep
Grewal, Harpreet Singh
Soles, Brian
Halbur, Luke
Surani, Salim
Kashyap, Rahul
author_facet Buddhavarapu, Venkata S.
Dhillon, Gagandeep
Grewal, Harpreet Singh
Soles, Brian
Halbur, Luke
Surani, Salim
Kashyap, Rahul
author_sort Buddhavarapu, Venkata S.
collection PubMed
description Pancreatic neuroendocrine tumors can be classified as functional or nonfunctional based on hormone secretion. Management of each entity is different, with nonfunctional tumors being treated with traditional chemotherapy while functional tumors respond well to antihormonal therapy and immunologic agents. The conversion of one nonfunctional tumor into a functional tumor is an exceedingly rare event that complicates the overall management of these patients. In this report, we present the case of a 73‐year‐old woman who developed the conversion from a nonfunctional into a functional tumor and discuss the management options considered.
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spelling pubmed-106279232023-11-08 Transformation of pancreatic nonfunctioning neuroendocrine tumor into metastatic insulinoma: A rare case report Buddhavarapu, Venkata S. Dhillon, Gagandeep Grewal, Harpreet Singh Soles, Brian Halbur, Luke Surani, Salim Kashyap, Rahul Clin Case Rep Case Report Pancreatic neuroendocrine tumors can be classified as functional or nonfunctional based on hormone secretion. Management of each entity is different, with nonfunctional tumors being treated with traditional chemotherapy while functional tumors respond well to antihormonal therapy and immunologic agents. The conversion of one nonfunctional tumor into a functional tumor is an exceedingly rare event that complicates the overall management of these patients. In this report, we present the case of a 73‐year‐old woman who developed the conversion from a nonfunctional into a functional tumor and discuss the management options considered. John Wiley and Sons Inc. 2023-11-06 /pmc/articles/PMC10627923/ /pubmed/37942181 http://dx.doi.org/10.1002/ccr3.8152 Text en © 2023 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Buddhavarapu, Venkata S.
Dhillon, Gagandeep
Grewal, Harpreet Singh
Soles, Brian
Halbur, Luke
Surani, Salim
Kashyap, Rahul
Transformation of pancreatic nonfunctioning neuroendocrine tumor into metastatic insulinoma: A rare case report
title Transformation of pancreatic nonfunctioning neuroendocrine tumor into metastatic insulinoma: A rare case report
title_full Transformation of pancreatic nonfunctioning neuroendocrine tumor into metastatic insulinoma: A rare case report
title_fullStr Transformation of pancreatic nonfunctioning neuroendocrine tumor into metastatic insulinoma: A rare case report
title_full_unstemmed Transformation of pancreatic nonfunctioning neuroendocrine tumor into metastatic insulinoma: A rare case report
title_short Transformation of pancreatic nonfunctioning neuroendocrine tumor into metastatic insulinoma: A rare case report
title_sort transformation of pancreatic nonfunctioning neuroendocrine tumor into metastatic insulinoma: a rare case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10627923/
https://www.ncbi.nlm.nih.gov/pubmed/37942181
http://dx.doi.org/10.1002/ccr3.8152
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