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Acute low back pain as infusion-related reaction to monoclonal antibodies

Monoclonal antibodies, such as PD-1 inhibitors, are increasingly used in various cancers. Acute low back pain as infusion-related reaction (IRR) to monoclonal antibodies is poorly described. We report a bicentric series of 10 cases of acute low back pain due to administration of monoclonal antibodie...

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Autores principales: Majenka, Pawel, Loquai, Carmen, Schöning, Tilman, Enk, Alexander, Hassel, Jessica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10627944/
https://www.ncbi.nlm.nih.gov/pubmed/37941549
http://dx.doi.org/10.3389/fonc.2023.1161818
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author Majenka, Pawel
Loquai, Carmen
Schöning, Tilman
Enk, Alexander
Hassel, Jessica
author_facet Majenka, Pawel
Loquai, Carmen
Schöning, Tilman
Enk, Alexander
Hassel, Jessica
author_sort Majenka, Pawel
collection PubMed
description Monoclonal antibodies, such as PD-1 inhibitors, are increasingly used in various cancers. Acute low back pain as infusion-related reaction (IRR) to monoclonal antibodies is poorly described. We report a bicentric series of 10 cases of acute low back pain due to administration of monoclonal antibodies directed against PD-1/PD-L1 for skin cancer treatment in patients treated at University Hospital Heidelberg and University Medical Center Mainz (Germany). The management of IRR symptoms was immediate interruption of infusion and analgesia leading to quick improvement and complete symptom relief in all patients. Our findings suggest that the risk of developing low back pain as IRR is depending on the concentration of the administered drug. Low back pain as IRR can be managed by early interruption of infusion and by decreasing the infusion rate or concentration in following administrations.
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spelling pubmed-106279442023-11-08 Acute low back pain as infusion-related reaction to monoclonal antibodies Majenka, Pawel Loquai, Carmen Schöning, Tilman Enk, Alexander Hassel, Jessica Front Oncol Oncology Monoclonal antibodies, such as PD-1 inhibitors, are increasingly used in various cancers. Acute low back pain as infusion-related reaction (IRR) to monoclonal antibodies is poorly described. We report a bicentric series of 10 cases of acute low back pain due to administration of monoclonal antibodies directed against PD-1/PD-L1 for skin cancer treatment in patients treated at University Hospital Heidelberg and University Medical Center Mainz (Germany). The management of IRR symptoms was immediate interruption of infusion and analgesia leading to quick improvement and complete symptom relief in all patients. Our findings suggest that the risk of developing low back pain as IRR is depending on the concentration of the administered drug. Low back pain as IRR can be managed by early interruption of infusion and by decreasing the infusion rate or concentration in following administrations. Frontiers Media S.A. 2023-10-24 /pmc/articles/PMC10627944/ /pubmed/37941549 http://dx.doi.org/10.3389/fonc.2023.1161818 Text en Copyright © 2023 Majenka, Loquai, Schöning, Enk and Hassel https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Majenka, Pawel
Loquai, Carmen
Schöning, Tilman
Enk, Alexander
Hassel, Jessica
Acute low back pain as infusion-related reaction to monoclonal antibodies
title Acute low back pain as infusion-related reaction to monoclonal antibodies
title_full Acute low back pain as infusion-related reaction to monoclonal antibodies
title_fullStr Acute low back pain as infusion-related reaction to monoclonal antibodies
title_full_unstemmed Acute low back pain as infusion-related reaction to monoclonal antibodies
title_short Acute low back pain as infusion-related reaction to monoclonal antibodies
title_sort acute low back pain as infusion-related reaction to monoclonal antibodies
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10627944/
https://www.ncbi.nlm.nih.gov/pubmed/37941549
http://dx.doi.org/10.3389/fonc.2023.1161818
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