Cargando…
Advances in the research of exosomes in renal cell carcinoma: from mechanisms to applications
Renal cell carcinoma (RCC) is one of the most malignant urological tumors. Currently, there is a lack of molecular markers for early diagnosis of RCC. The 5-year survival rate for early-stage RCC is generally favorable; however, the prognosis takes a significant downturn when the tumor progresses to...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10628008/ https://www.ncbi.nlm.nih.gov/pubmed/37942325 http://dx.doi.org/10.3389/fimmu.2023.1271669 |
_version_ | 1785131659750801408 |
---|---|
author | Rui, Rui Zhou, Liqun He, Shiming |
author_facet | Rui, Rui Zhou, Liqun He, Shiming |
author_sort | Rui, Rui |
collection | PubMed |
description | Renal cell carcinoma (RCC) is one of the most malignant urological tumors. Currently, there is a lack of molecular markers for early diagnosis of RCC. The 5-year survival rate for early-stage RCC is generally favorable; however, the prognosis takes a significant downturn when the tumor progresses to distant metastasis. Therefore, the identification of molecular markers for RCC is crucial in enhancing early diagnosis rates. Exosomes are a type of extracellular vesicle (EV) typically ranging in size from 30 nm to 150 nm, which contain RNA, DNA, proteins, lipids, etc. They can impact neighboring receptor cells through the autocrine or paracrine pathway, influence cellular communication, and regulate the local immune cells, consequently shaping the tumor immune microenvironment and closely associating with tumor development. The clinical application of exosomes as tumor markers and therapeutic targets has ignited significant interest within the research community. This review aims to provide a comprehensive summary of the advancements in exosome research within the context of RCC. |
format | Online Article Text |
id | pubmed-10628008 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-106280082023-11-08 Advances in the research of exosomes in renal cell carcinoma: from mechanisms to applications Rui, Rui Zhou, Liqun He, Shiming Front Immunol Immunology Renal cell carcinoma (RCC) is one of the most malignant urological tumors. Currently, there is a lack of molecular markers for early diagnosis of RCC. The 5-year survival rate for early-stage RCC is generally favorable; however, the prognosis takes a significant downturn when the tumor progresses to distant metastasis. Therefore, the identification of molecular markers for RCC is crucial in enhancing early diagnosis rates. Exosomes are a type of extracellular vesicle (EV) typically ranging in size from 30 nm to 150 nm, which contain RNA, DNA, proteins, lipids, etc. They can impact neighboring receptor cells through the autocrine or paracrine pathway, influence cellular communication, and regulate the local immune cells, consequently shaping the tumor immune microenvironment and closely associating with tumor development. The clinical application of exosomes as tumor markers and therapeutic targets has ignited significant interest within the research community. This review aims to provide a comprehensive summary of the advancements in exosome research within the context of RCC. Frontiers Media S.A. 2023-10-24 /pmc/articles/PMC10628008/ /pubmed/37942325 http://dx.doi.org/10.3389/fimmu.2023.1271669 Text en Copyright © 2023 Rui, Zhou and He https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Rui, Rui Zhou, Liqun He, Shiming Advances in the research of exosomes in renal cell carcinoma: from mechanisms to applications |
title | Advances in the research of exosomes in renal cell carcinoma: from mechanisms to applications |
title_full | Advances in the research of exosomes in renal cell carcinoma: from mechanisms to applications |
title_fullStr | Advances in the research of exosomes in renal cell carcinoma: from mechanisms to applications |
title_full_unstemmed | Advances in the research of exosomes in renal cell carcinoma: from mechanisms to applications |
title_short | Advances in the research of exosomes in renal cell carcinoma: from mechanisms to applications |
title_sort | advances in the research of exosomes in renal cell carcinoma: from mechanisms to applications |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10628008/ https://www.ncbi.nlm.nih.gov/pubmed/37942325 http://dx.doi.org/10.3389/fimmu.2023.1271669 |
work_keys_str_mv | AT ruirui advancesintheresearchofexosomesinrenalcellcarcinomafrommechanismstoapplications AT zhouliqun advancesintheresearchofexosomesinrenalcellcarcinomafrommechanismstoapplications AT heshiming advancesintheresearchofexosomesinrenalcellcarcinomafrommechanismstoapplications |