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Illicit drug use is associated with lower bone mineral density and bone strength

OBJECTIVES: To evaluate the association of illicit drug use with bone mineral density (BMD) and hip geometric parameters at the narrow neck. METHODS: This is a cross-sectional matched cohort study conducted in the Hong Kong Chinese population. Associations with illicit drug use were estimated using...

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Autores principales: Krishnamoorthy, Suhas, Li, Gloria Hoi-Yee, Ho, Kelvin Shun-Cheong, Chau, Yin-Pan, Mak, Constance, Ng, Donna, Chung, Albert Kar-Kin, Chu, Jody Kwok-Pui, Tan, Kathryn Choon-Beng, Hoo, Ruby Lai-Chong, Cheung, Ching-Lung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society of Osteoporosis 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10628013/
https://www.ncbi.nlm.nih.gov/pubmed/37941531
http://dx.doi.org/10.1016/j.afos.2023.09.001
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author Krishnamoorthy, Suhas
Li, Gloria Hoi-Yee
Ho, Kelvin Shun-Cheong
Chau, Yin-Pan
Mak, Constance
Ng, Donna
Chung, Albert Kar-Kin
Chu, Jody Kwok-Pui
Tan, Kathryn Choon-Beng
Hoo, Ruby Lai-Chong
Cheung, Ching-Lung
author_facet Krishnamoorthy, Suhas
Li, Gloria Hoi-Yee
Ho, Kelvin Shun-Cheong
Chau, Yin-Pan
Mak, Constance
Ng, Donna
Chung, Albert Kar-Kin
Chu, Jody Kwok-Pui
Tan, Kathryn Choon-Beng
Hoo, Ruby Lai-Chong
Cheung, Ching-Lung
author_sort Krishnamoorthy, Suhas
collection PubMed
description OBJECTIVES: To evaluate the association of illicit drug use with bone mineral density (BMD) and hip geometric parameters at the narrow neck. METHODS: This is a cross-sectional matched cohort study conducted in the Hong Kong Chinese population. Associations with illicit drug use were estimated using linear regression for BMD (lumbar spine and femoral neck) and hip geometrical parameters (cross-sectional area [CSA], cross-sectional moment of inertia [CSMI], section modulus [SM], average cortical thickness [ACT] and BMD at the narrow neck) after adjusting for age, body mass index (BMI), smoking status, drinking status, physical activity, and history of antipsychotic and antidepressant use. Mean difference and 95% confidence intervals (95% CI) were calculated between 108 illicit drug users and 108 controls using an adjusted linear model and cluster-robust standard errors after matching by age and sex. The false discovery rate was used to correct for multiple testing. RESULTS: Illicit drug users had a significantly lower BMD (g/cm(2)) at the lumbar spine (mean difference: −0.062; 95% CI: −0.108 to −0.015), and femoral neck (mean difference: −0.058; 95% CI: −0.106 to −0.010) in the fully adjusted model. Illicit drug users also had a significantly lower CSA (mean difference: −0.238 cm(2); 95% CI: −0.462 to −0.013), ACT (mean difference: −0.018 cm; 95% CI: −0.030 to −0.006) and BMD (mean difference: −0.070 g/cm(2); 95% CI: −0.128 to −0.012) at the narrow neck. CONCLUSIONS: Illicit drug use is associated with lower BMD and bone strength. Future studies evaluating the risk of illicit drug use with fragility fracture are warranted.
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spelling pubmed-106280132023-11-08 Illicit drug use is associated with lower bone mineral density and bone strength Krishnamoorthy, Suhas Li, Gloria Hoi-Yee Ho, Kelvin Shun-Cheong Chau, Yin-Pan Mak, Constance Ng, Donna Chung, Albert Kar-Kin Chu, Jody Kwok-Pui Tan, Kathryn Choon-Beng Hoo, Ruby Lai-Chong Cheung, Ching-Lung Osteoporos Sarcopenia Original Article OBJECTIVES: To evaluate the association of illicit drug use with bone mineral density (BMD) and hip geometric parameters at the narrow neck. METHODS: This is a cross-sectional matched cohort study conducted in the Hong Kong Chinese population. Associations with illicit drug use were estimated using linear regression for BMD (lumbar spine and femoral neck) and hip geometrical parameters (cross-sectional area [CSA], cross-sectional moment of inertia [CSMI], section modulus [SM], average cortical thickness [ACT] and BMD at the narrow neck) after adjusting for age, body mass index (BMI), smoking status, drinking status, physical activity, and history of antipsychotic and antidepressant use. Mean difference and 95% confidence intervals (95% CI) were calculated between 108 illicit drug users and 108 controls using an adjusted linear model and cluster-robust standard errors after matching by age and sex. The false discovery rate was used to correct for multiple testing. RESULTS: Illicit drug users had a significantly lower BMD (g/cm(2)) at the lumbar spine (mean difference: −0.062; 95% CI: −0.108 to −0.015), and femoral neck (mean difference: −0.058; 95% CI: −0.106 to −0.010) in the fully adjusted model. Illicit drug users also had a significantly lower CSA (mean difference: −0.238 cm(2); 95% CI: −0.462 to −0.013), ACT (mean difference: −0.018 cm; 95% CI: −0.030 to −0.006) and BMD (mean difference: −0.070 g/cm(2); 95% CI: −0.128 to −0.012) at the narrow neck. CONCLUSIONS: Illicit drug use is associated with lower BMD and bone strength. Future studies evaluating the risk of illicit drug use with fragility fracture are warranted. Korean Society of Osteoporosis 2023-09 2023-09-19 /pmc/articles/PMC10628013/ /pubmed/37941531 http://dx.doi.org/10.1016/j.afos.2023.09.001 Text en © 2023 The Korean Society of Osteoporosis. Publishing services by Elsevier B.V. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Krishnamoorthy, Suhas
Li, Gloria Hoi-Yee
Ho, Kelvin Shun-Cheong
Chau, Yin-Pan
Mak, Constance
Ng, Donna
Chung, Albert Kar-Kin
Chu, Jody Kwok-Pui
Tan, Kathryn Choon-Beng
Hoo, Ruby Lai-Chong
Cheung, Ching-Lung
Illicit drug use is associated with lower bone mineral density and bone strength
title Illicit drug use is associated with lower bone mineral density and bone strength
title_full Illicit drug use is associated with lower bone mineral density and bone strength
title_fullStr Illicit drug use is associated with lower bone mineral density and bone strength
title_full_unstemmed Illicit drug use is associated with lower bone mineral density and bone strength
title_short Illicit drug use is associated with lower bone mineral density and bone strength
title_sort illicit drug use is associated with lower bone mineral density and bone strength
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10628013/
https://www.ncbi.nlm.nih.gov/pubmed/37941531
http://dx.doi.org/10.1016/j.afos.2023.09.001
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