Activation of the integrated stress response rewires cardiac metabolism in Barth syndrome

Barth Syndrome (BTHS) is an inherited cardiomyopathy caused by defects in the mitochondrial transacylase TAFAZZIN (Taz), required for the synthesis of the phospholipid cardiolipin. BTHS is characterized by heart failure, increased propensity for arrhythmias and a blunted inotropic reserve. Defects i...

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Detalles Bibliográficos
Autores principales: Kutschka, Ilona, Bertero, Edoardo, Wasmus, Christina, Xiao, Ke, Yang, Lifeng, Chen, Xinyu, Oshima, Yasuhiro, Fischer, Marcus, Erk, Manuela, Arslan, Berkan, Alhasan, Lin, Grosser, Daria, Ermer, Katharina J., Nickel, Alexander, Kohlhaas, Michael, Eberl, Hanna, Rebs, Sabine, Streckfuss-Bömeke, Katrin, Schmitz, Werner, Rehling, Peter, Thum, Thomas, Higuchi, Takahiro, Rabinowitz, Joshua, Maack, Christoph, Dudek, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Original Contribution
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10628049/
https://www.ncbi.nlm.nih.gov/pubmed/37930434
http://dx.doi.org/10.1007/s00395-023-01017-x

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