Targeting oncogenic microRNAs from the miR-371~373 and miR-302/367 clusters in malignant germ cell tumours causes growth inhibition through cell cycle disruption

BACKGROUND: MiR-371~373 and miR-302/367 cluster over-expression occurs in all malignant germ cell tumours (GCTs), regardless of age (paediatric/adult), site (gonadal/extragonadal), or subtype [seminoma, yolk sac tumour (YST), embryonal carcinoma (EC)]. Six of eight microRNAs from these clusters cont...

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Detalles Bibliográficos
Autores principales: Bailey, Shivani, Ferraresso, Marta, Alonso-Crisostomo, Luz, Ward, Dawn, Smith, Stephen, Nicholson, James C., Saini, Harpreet, Enright, Anton J., Scarpini, Cinzia G., Coleman, Nicholas, Murray, Matthew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10628203/
https://www.ncbi.nlm.nih.gov/pubmed/37789102
http://dx.doi.org/10.1038/s41416-023-02453-1

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