Mesenchymal stem cells under epigenetic control – the role of epigenetic machinery in fate decision and functional properties

Mesenchymal stem cells (mesenchymal stromal cells, MSC) are multipotent stem cells that can differentiate into cells of at least three mesodermal lineages, namely adipocytes, osteoblasts, and chondrocytes, and have potent immunomodulatory properties. Epigenetic modifications are critical regulators...

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Autores principales: Walewska, Alicja, Janucik, Adrian, Tynecka, Marlena, Moniuszko, Marcin, Eljaszewicz, Andrzej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10628230/
https://www.ncbi.nlm.nih.gov/pubmed/37932257
http://dx.doi.org/10.1038/s41419-023-06239-4
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author Walewska, Alicja
Janucik, Adrian
Tynecka, Marlena
Moniuszko, Marcin
Eljaszewicz, Andrzej
author_facet Walewska, Alicja
Janucik, Adrian
Tynecka, Marlena
Moniuszko, Marcin
Eljaszewicz, Andrzej
author_sort Walewska, Alicja
collection PubMed
description Mesenchymal stem cells (mesenchymal stromal cells, MSC) are multipotent stem cells that can differentiate into cells of at least three mesodermal lineages, namely adipocytes, osteoblasts, and chondrocytes, and have potent immunomodulatory properties. Epigenetic modifications are critical regulators of gene expression and cellular differentiation of mesenchymal stem cells (MSCs). Epigenetic machinery controls MSC differentiation through direct modifications to DNA and histones. Understanding the role of epigenetic machinery in MSC is crucial for the development of effective cell-based therapies for degenerative and inflammatory diseases. In this review, we summarize the current understanding of the role of epigenetic control of MSC differentiation and immunomodulatory properties.
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spelling pubmed-106282302023-11-08 Mesenchymal stem cells under epigenetic control – the role of epigenetic machinery in fate decision and functional properties Walewska, Alicja Janucik, Adrian Tynecka, Marlena Moniuszko, Marcin Eljaszewicz, Andrzej Cell Death Dis Review Article Mesenchymal stem cells (mesenchymal stromal cells, MSC) are multipotent stem cells that can differentiate into cells of at least three mesodermal lineages, namely adipocytes, osteoblasts, and chondrocytes, and have potent immunomodulatory properties. Epigenetic modifications are critical regulators of gene expression and cellular differentiation of mesenchymal stem cells (MSCs). Epigenetic machinery controls MSC differentiation through direct modifications to DNA and histones. Understanding the role of epigenetic machinery in MSC is crucial for the development of effective cell-based therapies for degenerative and inflammatory diseases. In this review, we summarize the current understanding of the role of epigenetic control of MSC differentiation and immunomodulatory properties. Nature Publishing Group UK 2023-11-06 /pmc/articles/PMC10628230/ /pubmed/37932257 http://dx.doi.org/10.1038/s41419-023-06239-4 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Walewska, Alicja
Janucik, Adrian
Tynecka, Marlena
Moniuszko, Marcin
Eljaszewicz, Andrzej
Mesenchymal stem cells under epigenetic control – the role of epigenetic machinery in fate decision and functional properties
title Mesenchymal stem cells under epigenetic control – the role of epigenetic machinery in fate decision and functional properties
title_full Mesenchymal stem cells under epigenetic control – the role of epigenetic machinery in fate decision and functional properties
title_fullStr Mesenchymal stem cells under epigenetic control – the role of epigenetic machinery in fate decision and functional properties
title_full_unstemmed Mesenchymal stem cells under epigenetic control – the role of epigenetic machinery in fate decision and functional properties
title_short Mesenchymal stem cells under epigenetic control – the role of epigenetic machinery in fate decision and functional properties
title_sort mesenchymal stem cells under epigenetic control – the role of epigenetic machinery in fate decision and functional properties
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10628230/
https://www.ncbi.nlm.nih.gov/pubmed/37932257
http://dx.doi.org/10.1038/s41419-023-06239-4
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