Identification of the flavivirus conserved residues in the envelope protein hinge region for the rational design of a candidate West Nile live-attenuated vaccine

The flavivirus envelope protein is a class II fusion protein that drives flavivirus-cell membrane fusion. The membrane fusion process is triggered by the conformational change of the E protein from dimer in the virion to trimer, which involves the rearrangement of three domains, EDI, EDII, and EDIII...

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Detalles Bibliográficos
Autores principales: Maloney, Bailey E., Carpio, Kassandra L., Bilyeu, Ashley N., Saunders, Danielle R. D., Park, So Lee, Pohl, Adrienne E., Ball, Natalia Costa, Raetz, Janae L., Huang, Claire Y., Higgs, Stephen, Barrett, Alan D. T., Roman-Sosa, Gleyder, Kenney, Joanie L., Vanlandingham, Dana L., Huang, Yan-Jang S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10628263/
https://www.ncbi.nlm.nih.gov/pubmed/37932282
http://dx.doi.org/10.1038/s41541-023-00765-0

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