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Hippocampal volume mediates the relationship of parental rejection in childhood with social cognition in healthy adults
Childhood abuse reduces hippocampal and amygdala volumes and impairs social cognition, including the ability to recognize facial expressions. However, these associations have been studied primarily in individuals with a history of severe abuse and psychiatric symptoms; researchers have not determine...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10628272/ https://www.ncbi.nlm.nih.gov/pubmed/37932349 http://dx.doi.org/10.1038/s41598-023-46512-2 |
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author | Kawamoto, Marino Takagishi, Haruto Ishihara, Toru Takagi, Shunsuke Kanai, Ryota Sugihara, Genichi Takahashi, Hidehiko Matsuda, Tetsuya |
author_facet | Kawamoto, Marino Takagishi, Haruto Ishihara, Toru Takagi, Shunsuke Kanai, Ryota Sugihara, Genichi Takahashi, Hidehiko Matsuda, Tetsuya |
author_sort | Kawamoto, Marino |
collection | PubMed |
description | Childhood abuse reduces hippocampal and amygdala volumes and impairs social cognition, including the ability to recognize facial expressions. However, these associations have been studied primarily in individuals with a history of severe abuse and psychiatric symptoms; researchers have not determined whether these associations can also be observed in healthy adults. In the present study, we analyzed data from 400 healthy adults (208 men and 192 women) at Tamagawa University. Parental rejection reflecting childhood abuse was assessed using the short form of Egna Minnen Beträffande Uppfostran, while social cognition was assessed using the “Fake Smile Detection Task.” Hippocampal and amygdala volumes were extracted from T1-weighted magnetic resonance imaging data using FreeSurfer. We found that greater parental rejection resulted in smaller hippocampal and amygdala volumes and poorer performance in the Fake Smile Detection Task. Structural equation modeling analysis supported the model that hippocampal volume mediates maternal rejection effect on performance on the Fake Smile Detection Task, with involvement of the amygdala. These findings are in line with the structural and functional connectivity found between the hippocampus and amygdala and their joint involvement in social cognition. Therefore, parental rejection may affect hippocampal and amygdala volumes and social cognitive function even in symptom-free adults. |
format | Online Article Text |
id | pubmed-10628272 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-106282722023-11-08 Hippocampal volume mediates the relationship of parental rejection in childhood with social cognition in healthy adults Kawamoto, Marino Takagishi, Haruto Ishihara, Toru Takagi, Shunsuke Kanai, Ryota Sugihara, Genichi Takahashi, Hidehiko Matsuda, Tetsuya Sci Rep Article Childhood abuse reduces hippocampal and amygdala volumes and impairs social cognition, including the ability to recognize facial expressions. However, these associations have been studied primarily in individuals with a history of severe abuse and psychiatric symptoms; researchers have not determined whether these associations can also be observed in healthy adults. In the present study, we analyzed data from 400 healthy adults (208 men and 192 women) at Tamagawa University. Parental rejection reflecting childhood abuse was assessed using the short form of Egna Minnen Beträffande Uppfostran, while social cognition was assessed using the “Fake Smile Detection Task.” Hippocampal and amygdala volumes were extracted from T1-weighted magnetic resonance imaging data using FreeSurfer. We found that greater parental rejection resulted in smaller hippocampal and amygdala volumes and poorer performance in the Fake Smile Detection Task. Structural equation modeling analysis supported the model that hippocampal volume mediates maternal rejection effect on performance on the Fake Smile Detection Task, with involvement of the amygdala. These findings are in line with the structural and functional connectivity found between the hippocampus and amygdala and their joint involvement in social cognition. Therefore, parental rejection may affect hippocampal and amygdala volumes and social cognitive function even in symptom-free adults. Nature Publishing Group UK 2023-11-06 /pmc/articles/PMC10628272/ /pubmed/37932349 http://dx.doi.org/10.1038/s41598-023-46512-2 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Kawamoto, Marino Takagishi, Haruto Ishihara, Toru Takagi, Shunsuke Kanai, Ryota Sugihara, Genichi Takahashi, Hidehiko Matsuda, Tetsuya Hippocampal volume mediates the relationship of parental rejection in childhood with social cognition in healthy adults |
title | Hippocampal volume mediates the relationship of parental rejection in childhood with social cognition in healthy adults |
title_full | Hippocampal volume mediates the relationship of parental rejection in childhood with social cognition in healthy adults |
title_fullStr | Hippocampal volume mediates the relationship of parental rejection in childhood with social cognition in healthy adults |
title_full_unstemmed | Hippocampal volume mediates the relationship of parental rejection in childhood with social cognition in healthy adults |
title_short | Hippocampal volume mediates the relationship of parental rejection in childhood with social cognition in healthy adults |
title_sort | hippocampal volume mediates the relationship of parental rejection in childhood with social cognition in healthy adults |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10628272/ https://www.ncbi.nlm.nih.gov/pubmed/37932349 http://dx.doi.org/10.1038/s41598-023-46512-2 |
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