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Occupational exposure to pesticides dysregulates systemic Th1/Th2/Th17 cytokines and correlates with poor clinical outcomes in breast cancer patients

Pesticides are compounds known to cause immunetoxicity in exposed individuals, which have a potential to substantially modify the prognosis of pathologies dependent on an efficient immune response, such as breast cancer. In this context, we examined the circulating cytokine profile of Th1/Th2/Th17 p...

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Autores principales: dos Santos, Stephany Bonin Godinho, da Silva, Janaína Carla, Jaques, Hellen dos Santos, Dalla Vecchia, Marina Ferronato, Ferreira, Mariane Okamoto, Rech, Daniel, Sierota da Silva, Matheus Ryan Noah, dos Santos, Roberta Bonin Godinho, Panis, Carolina, Benvegnú, Dalila Moter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10628301/
https://www.ncbi.nlm.nih.gov/pubmed/37942322
http://dx.doi.org/10.3389/fimmu.2023.1281056
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author dos Santos, Stephany Bonin Godinho
da Silva, Janaína Carla
Jaques, Hellen dos Santos
Dalla Vecchia, Marina Ferronato
Ferreira, Mariane Okamoto
Rech, Daniel
Sierota da Silva, Matheus Ryan Noah
dos Santos, Roberta Bonin Godinho
Panis, Carolina
Benvegnú, Dalila Moter
author_facet dos Santos, Stephany Bonin Godinho
da Silva, Janaína Carla
Jaques, Hellen dos Santos
Dalla Vecchia, Marina Ferronato
Ferreira, Mariane Okamoto
Rech, Daniel
Sierota da Silva, Matheus Ryan Noah
dos Santos, Roberta Bonin Godinho
Panis, Carolina
Benvegnú, Dalila Moter
author_sort dos Santos, Stephany Bonin Godinho
collection PubMed
description Pesticides are compounds known to cause immunetoxicity in exposed individuals, which have a potential to substantially modify the prognosis of pathologies dependent on an efficient immune response, such as breast cancer. In this context, we examined the circulating cytokine profile of Th1/Th2/Th17 patterns in women occupationally exposed to pesticides and their correlation with worse prognostic outcomes. Peripheral blood samples were collected from 187 rural working women with breast cancer, occupationally exposed or not to pesticides, to quantify the levels of cytokines IL-1β, IL-12, IL-4, IL-17-A, and TNF -α. Data on the disease profile and clinical outcomes were collected through medical follow-up. IL-12 was reduced in exposed women with tumors larger than 2 cm and in those with lymph node metastases. Significantly reduced levels of IL-17A were observed in exposed patients with Luminal B subtype tumors, with high ki67 proliferation rates, high histological grade, and positive for the progesterone receptor. Reduced IL-4 was also seen in exposed women with lymph node invasion. Our data show that occupational exposure to pesticides induces significant changes in the levels of cytokines necessary for tumor control and correlates with poor prognosis clinical outcomes in breast cancer.
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spelling pubmed-106283012023-11-08 Occupational exposure to pesticides dysregulates systemic Th1/Th2/Th17 cytokines and correlates with poor clinical outcomes in breast cancer patients dos Santos, Stephany Bonin Godinho da Silva, Janaína Carla Jaques, Hellen dos Santos Dalla Vecchia, Marina Ferronato Ferreira, Mariane Okamoto Rech, Daniel Sierota da Silva, Matheus Ryan Noah dos Santos, Roberta Bonin Godinho Panis, Carolina Benvegnú, Dalila Moter Front Immunol Immunology Pesticides are compounds known to cause immunetoxicity in exposed individuals, which have a potential to substantially modify the prognosis of pathologies dependent on an efficient immune response, such as breast cancer. In this context, we examined the circulating cytokine profile of Th1/Th2/Th17 patterns in women occupationally exposed to pesticides and their correlation with worse prognostic outcomes. Peripheral blood samples were collected from 187 rural working women with breast cancer, occupationally exposed or not to pesticides, to quantify the levels of cytokines IL-1β, IL-12, IL-4, IL-17-A, and TNF -α. Data on the disease profile and clinical outcomes were collected through medical follow-up. IL-12 was reduced in exposed women with tumors larger than 2 cm and in those with lymph node metastases. Significantly reduced levels of IL-17A were observed in exposed patients with Luminal B subtype tumors, with high ki67 proliferation rates, high histological grade, and positive for the progesterone receptor. Reduced IL-4 was also seen in exposed women with lymph node invasion. Our data show that occupational exposure to pesticides induces significant changes in the levels of cytokines necessary for tumor control and correlates with poor prognosis clinical outcomes in breast cancer. Frontiers Media S.A. 2023-10-24 /pmc/articles/PMC10628301/ /pubmed/37942322 http://dx.doi.org/10.3389/fimmu.2023.1281056 Text en Copyright © 2023 Santos, da Silva, Jaques, Dalla Vecchia, Ferreira, Rech, Sierota da Silva, Santos, Panis and Benvegnú https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
dos Santos, Stephany Bonin Godinho
da Silva, Janaína Carla
Jaques, Hellen dos Santos
Dalla Vecchia, Marina Ferronato
Ferreira, Mariane Okamoto
Rech, Daniel
Sierota da Silva, Matheus Ryan Noah
dos Santos, Roberta Bonin Godinho
Panis, Carolina
Benvegnú, Dalila Moter
Occupational exposure to pesticides dysregulates systemic Th1/Th2/Th17 cytokines and correlates with poor clinical outcomes in breast cancer patients
title Occupational exposure to pesticides dysregulates systemic Th1/Th2/Th17 cytokines and correlates with poor clinical outcomes in breast cancer patients
title_full Occupational exposure to pesticides dysregulates systemic Th1/Th2/Th17 cytokines and correlates with poor clinical outcomes in breast cancer patients
title_fullStr Occupational exposure to pesticides dysregulates systemic Th1/Th2/Th17 cytokines and correlates with poor clinical outcomes in breast cancer patients
title_full_unstemmed Occupational exposure to pesticides dysregulates systemic Th1/Th2/Th17 cytokines and correlates with poor clinical outcomes in breast cancer patients
title_short Occupational exposure to pesticides dysregulates systemic Th1/Th2/Th17 cytokines and correlates with poor clinical outcomes in breast cancer patients
title_sort occupational exposure to pesticides dysregulates systemic th1/th2/th17 cytokines and correlates with poor clinical outcomes in breast cancer patients
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10628301/
https://www.ncbi.nlm.nih.gov/pubmed/37942322
http://dx.doi.org/10.3389/fimmu.2023.1281056
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