Cargando…
Lesson of urgent bilateral lobar lung transplantation for acute fibrinous and organizing pneumonia: a case report
BACKGROUND: Acute fibrinous and organizing pneumonia (AFOP) is one of acute expiratory diseases, which occurs rarely with a difficult diagnosis. AFOP is related to an idiopathic cause or autoimmune disease, drug use, infection, cancer, or transplantation. Variation of treatment depends on different...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
AME Publishing Company
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10628395/ https://www.ncbi.nlm.nih.gov/pubmed/37942045 http://dx.doi.org/10.21037/acr-22-88 |
_version_ | 1785131747502981120 |
---|---|
author | Ye, Bing Chen, Chun Huang, Lin Chen, Jingyu Weng, Qinyong Wu, Weidong |
author_facet | Ye, Bing Chen, Chun Huang, Lin Chen, Jingyu Weng, Qinyong Wu, Weidong |
author_sort | Ye, Bing |
collection | PubMed |
description | BACKGROUND: Acute fibrinous and organizing pneumonia (AFOP) is one of acute expiratory diseases, which occurs rarely with a difficult diagnosis. AFOP is related to an idiopathic cause or autoimmune disease, drug use, infection, cancer, or transplantation. Variation of treatment depends on different institutions. To date, no evidence shows that lobar lung transplantation is applied in an urgent situation such as AFOP. CASE DESCRIPTION: A 33-year-old female patient experienced fever, cough, and dyspnea four days prior to admission. She had no underlying health conditions. Initially, she received oxygen therapy and empiric antimicrobial treatment, but later developed pulmonary consolidation. Pathological examination confirmed the diagnosis of AFOP. Despite receiving standardized treatment involving extracorporeal membrane oxygenation (ECMO) and mechanical ventilation, the patient’s respiratory function remained compromised. Consequently, an urgent lobar lung transplantation was performed. However, the patient encountered several challenges including carbapenem-resistant Pseudomonas aeruginosa pneumonia, exophytic granulation tissue, anastomotic stenosis, bronchopleural fistulae, anastomotic infections, septic shock, bacteremia, reperfusion syndrome, primary graft dysfunction, severe renal failure, and critical illness myopathy. Although the patient ultimately recovered and had a favorable survival outcome over 1-year post-discharge through multidisciplinary care, there are several key points to consider. Based on the findings from a systematic review, urgent transplantation may be a potential alternative treatment for AFOP. However, peri-transplantation programs should be enhanced, particularly regarding criteria selection, ECMO management, and the role of enhanced recovery after transplantation. CONCLUSIONS: The case demonstrates the feasibility of bilateral lobar lung transplantation in patients with AFOP, especially in an urgent situation. |
format | Online Article Text |
id | pubmed-10628395 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | AME Publishing Company |
record_format | MEDLINE/PubMed |
spelling | pubmed-106283952023-11-08 Lesson of urgent bilateral lobar lung transplantation for acute fibrinous and organizing pneumonia: a case report Ye, Bing Chen, Chun Huang, Lin Chen, Jingyu Weng, Qinyong Wu, Weidong AME Case Rep Case Report BACKGROUND: Acute fibrinous and organizing pneumonia (AFOP) is one of acute expiratory diseases, which occurs rarely with a difficult diagnosis. AFOP is related to an idiopathic cause or autoimmune disease, drug use, infection, cancer, or transplantation. Variation of treatment depends on different institutions. To date, no evidence shows that lobar lung transplantation is applied in an urgent situation such as AFOP. CASE DESCRIPTION: A 33-year-old female patient experienced fever, cough, and dyspnea four days prior to admission. She had no underlying health conditions. Initially, she received oxygen therapy and empiric antimicrobial treatment, but later developed pulmonary consolidation. Pathological examination confirmed the diagnosis of AFOP. Despite receiving standardized treatment involving extracorporeal membrane oxygenation (ECMO) and mechanical ventilation, the patient’s respiratory function remained compromised. Consequently, an urgent lobar lung transplantation was performed. However, the patient encountered several challenges including carbapenem-resistant Pseudomonas aeruginosa pneumonia, exophytic granulation tissue, anastomotic stenosis, bronchopleural fistulae, anastomotic infections, septic shock, bacteremia, reperfusion syndrome, primary graft dysfunction, severe renal failure, and critical illness myopathy. Although the patient ultimately recovered and had a favorable survival outcome over 1-year post-discharge through multidisciplinary care, there are several key points to consider. Based on the findings from a systematic review, urgent transplantation may be a potential alternative treatment for AFOP. However, peri-transplantation programs should be enhanced, particularly regarding criteria selection, ECMO management, and the role of enhanced recovery after transplantation. CONCLUSIONS: The case demonstrates the feasibility of bilateral lobar lung transplantation in patients with AFOP, especially in an urgent situation. AME Publishing Company 2023-09-21 /pmc/articles/PMC10628395/ /pubmed/37942045 http://dx.doi.org/10.21037/acr-22-88 Text en 2023 AME Case Reports. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) . |
spellingShingle | Case Report Ye, Bing Chen, Chun Huang, Lin Chen, Jingyu Weng, Qinyong Wu, Weidong Lesson of urgent bilateral lobar lung transplantation for acute fibrinous and organizing pneumonia: a case report |
title | Lesson of urgent bilateral lobar lung transplantation for acute fibrinous and organizing pneumonia: a case report |
title_full | Lesson of urgent bilateral lobar lung transplantation for acute fibrinous and organizing pneumonia: a case report |
title_fullStr | Lesson of urgent bilateral lobar lung transplantation for acute fibrinous and organizing pneumonia: a case report |
title_full_unstemmed | Lesson of urgent bilateral lobar lung transplantation for acute fibrinous and organizing pneumonia: a case report |
title_short | Lesson of urgent bilateral lobar lung transplantation for acute fibrinous and organizing pneumonia: a case report |
title_sort | lesson of urgent bilateral lobar lung transplantation for acute fibrinous and organizing pneumonia: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10628395/ https://www.ncbi.nlm.nih.gov/pubmed/37942045 http://dx.doi.org/10.21037/acr-22-88 |
work_keys_str_mv | AT yebing lessonofurgentbilaterallobarlungtransplantationforacutefibrinousandorganizingpneumoniaacasereport AT chenchun lessonofurgentbilaterallobarlungtransplantationforacutefibrinousandorganizingpneumoniaacasereport AT huanglin lessonofurgentbilaterallobarlungtransplantationforacutefibrinousandorganizingpneumoniaacasereport AT chenjingyu lessonofurgentbilaterallobarlungtransplantationforacutefibrinousandorganizingpneumoniaacasereport AT wengqinyong lessonofurgentbilaterallobarlungtransplantationforacutefibrinousandorganizingpneumoniaacasereport AT wuweidong lessonofurgentbilaterallobarlungtransplantationforacutefibrinousandorganizingpneumoniaacasereport |