Cattle-derived knob paratopes grafted onto peripheral loops of the IgG1 Fc region enable the generation of a novel symmetric bispecific antibody format

In this work we present a novel symmetric bispecific antibody format based on engraftments of cattle-derived knob paratopes onto peripheral loops of the IgG1 Fc region. For this, knob architectures obtained from bovine ultralong CDR-H3 antibodies were inserted into the AB loop or EF loop of the CH3...

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Detalles Bibliográficos
Autores principales: Yanakieva, Desislava, Vollmer, Lena, Evers, Andreas, Siegmund, Vanessa, Arras, Paul, Pekar, Lukas, Doerner, Achim, Valldorf, Bernhard, Kolmar, Harald, Zielonka, Stefan, Krah, Simon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10628450/
https://www.ncbi.nlm.nih.gov/pubmed/37942319
http://dx.doi.org/10.3389/fimmu.2023.1238313

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