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Management and clinical outcomes of follicular lymphoma across continuous lines of treatments: a retrospective analysis in China
BACKGROUND: Follicular lymphoma (FL) is characterized by an incurable course that frequently necessitates multiple lines of treatment. While a range of new approaches have broadened therapeutic options for patients in later lines, data regarding treatment patterns and outcomes of Chinese patients wi...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10628462/ https://www.ncbi.nlm.nih.gov/pubmed/37941553 http://dx.doi.org/10.3389/fonc.2023.1264723 |
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author | Liu, Jiaxin Hu, Yunfei Zhao, Linjun Nuersulitan, Reyizha Liu, Yanfei Yu, Hui Ye, Yingying Wang, Dedao Tang, Yongjing Feng, Feier Liu, Weiping Zhu, Jun Ping, Lingyan Song, Yuqin |
author_facet | Liu, Jiaxin Hu, Yunfei Zhao, Linjun Nuersulitan, Reyizha Liu, Yanfei Yu, Hui Ye, Yingying Wang, Dedao Tang, Yongjing Feng, Feier Liu, Weiping Zhu, Jun Ping, Lingyan Song, Yuqin |
author_sort | Liu, Jiaxin |
collection | PubMed |
description | BACKGROUND: Follicular lymphoma (FL) is characterized by an incurable course that frequently necessitates multiple lines of treatment. While a range of new approaches have broadened therapeutic options for patients in later lines, data regarding treatment patterns and outcomes of Chinese patients with relapsed/refractory(R/R) FL was scarcely reported. METHODS: This retrospective single-center study included patients diagnosed with FL grades 1–3a at our institution between January 2002 and December 2019. Endpoints of interest were analyzed according to lines and types of interventions. The endpoints mainly included overall response rate (ORR), progression-free survival (PFS), and overall survival (OS). RESULTS: The study enrolled 566 biopsy-proven patients. Among them, 544 patients initiated the first line of treatment, followed by 240 initiating the second line, 146 initiating the third line, 88 initiating the fourth line, 47 initiating the fifth line, and 28 initiating the sixth line. In terms of treatment patterns, anti-CD20 chemotherapy was a major modality in the first and second lines. However, for patients in the third line and subsequent lines, treatment approaches were diverse, and participation in clinical trials for new medications was common, which correlated with a survival benefit. The study also revealed that clinical indicators (such as ORR, PFS, and OS) gradually decreased with each subsequent line of treatment. The ORR at the first line was 86.6%, but decreased to 48.6% at the third line and 40.4% at the sixth line, respectively. Similarly, median OS and PFS decreased to 88.8 and 7.1 months at the third line and further reduced to 21.7 and 2.8 months at the sixth line, respectively. A total of 133 patients developed progression within 24 months from the initiation of first line anti-CD20 chemotherapy (POD24), and these patients exhibited poorer response rates and outcomes in subsequent lines of therapycompared to the non-POD24 group. CONCLUSION: This study revealed the clinical routine practices and prognosis of R/R FL patients within the Chinese population. It underscored the unmet need for optimal strategies to improve survival and also served as a benchmark for future trials. |
format | Online Article Text |
id | pubmed-10628462 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-106284622023-11-08 Management and clinical outcomes of follicular lymphoma across continuous lines of treatments: a retrospective analysis in China Liu, Jiaxin Hu, Yunfei Zhao, Linjun Nuersulitan, Reyizha Liu, Yanfei Yu, Hui Ye, Yingying Wang, Dedao Tang, Yongjing Feng, Feier Liu, Weiping Zhu, Jun Ping, Lingyan Song, Yuqin Front Oncol Oncology BACKGROUND: Follicular lymphoma (FL) is characterized by an incurable course that frequently necessitates multiple lines of treatment. While a range of new approaches have broadened therapeutic options for patients in later lines, data regarding treatment patterns and outcomes of Chinese patients with relapsed/refractory(R/R) FL was scarcely reported. METHODS: This retrospective single-center study included patients diagnosed with FL grades 1–3a at our institution between January 2002 and December 2019. Endpoints of interest were analyzed according to lines and types of interventions. The endpoints mainly included overall response rate (ORR), progression-free survival (PFS), and overall survival (OS). RESULTS: The study enrolled 566 biopsy-proven patients. Among them, 544 patients initiated the first line of treatment, followed by 240 initiating the second line, 146 initiating the third line, 88 initiating the fourth line, 47 initiating the fifth line, and 28 initiating the sixth line. In terms of treatment patterns, anti-CD20 chemotherapy was a major modality in the first and second lines. However, for patients in the third line and subsequent lines, treatment approaches were diverse, and participation in clinical trials for new medications was common, which correlated with a survival benefit. The study also revealed that clinical indicators (such as ORR, PFS, and OS) gradually decreased with each subsequent line of treatment. The ORR at the first line was 86.6%, but decreased to 48.6% at the third line and 40.4% at the sixth line, respectively. Similarly, median OS and PFS decreased to 88.8 and 7.1 months at the third line and further reduced to 21.7 and 2.8 months at the sixth line, respectively. A total of 133 patients developed progression within 24 months from the initiation of first line anti-CD20 chemotherapy (POD24), and these patients exhibited poorer response rates and outcomes in subsequent lines of therapycompared to the non-POD24 group. CONCLUSION: This study revealed the clinical routine practices and prognosis of R/R FL patients within the Chinese population. It underscored the unmet need for optimal strategies to improve survival and also served as a benchmark for future trials. Frontiers Media S.A. 2023-10-24 /pmc/articles/PMC10628462/ /pubmed/37941553 http://dx.doi.org/10.3389/fonc.2023.1264723 Text en Copyright © 2023 Liu, Hu, Zhao, Nuersulitan, Liu, Yu, Ye, Wang, Tang, Feng, Liu, Zhu, Ping and Song https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Liu, Jiaxin Hu, Yunfei Zhao, Linjun Nuersulitan, Reyizha Liu, Yanfei Yu, Hui Ye, Yingying Wang, Dedao Tang, Yongjing Feng, Feier Liu, Weiping Zhu, Jun Ping, Lingyan Song, Yuqin Management and clinical outcomes of follicular lymphoma across continuous lines of treatments: a retrospective analysis in China |
title | Management and clinical outcomes of follicular lymphoma across continuous lines of treatments: a retrospective analysis in China |
title_full | Management and clinical outcomes of follicular lymphoma across continuous lines of treatments: a retrospective analysis in China |
title_fullStr | Management and clinical outcomes of follicular lymphoma across continuous lines of treatments: a retrospective analysis in China |
title_full_unstemmed | Management and clinical outcomes of follicular lymphoma across continuous lines of treatments: a retrospective analysis in China |
title_short | Management and clinical outcomes of follicular lymphoma across continuous lines of treatments: a retrospective analysis in China |
title_sort | management and clinical outcomes of follicular lymphoma across continuous lines of treatments: a retrospective analysis in china |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10628462/ https://www.ncbi.nlm.nih.gov/pubmed/37941553 http://dx.doi.org/10.3389/fonc.2023.1264723 |
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